C₁₁H₁₃F₂I

Base Information

• Chemical Name: C₁₁H₁₃F₂I
• CAS No.: 147437-93-2
• Molecular Formula: C₁₁H₁₃F₂I
• Molecular Weight: 310.126
• Mol file: 147437-93-2.mol

Synonyms:

Chemical Property of C₁₁H₁₃F₂I

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₁H₁₃F₂I

There total 4 articles about C₁₁H₁₃F₂I which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,5-difluoro-1-pentylbenzene (121219-25-8) → C11H13F2I (147437-93-2)

Guidance literature:

3,5-difluoro-1-pentylbenzene; With n-butyllithium; In tetrahydrofuran; at -70 ℃;

With iodine; In tetrahydrofuran; at -70 ℃;

DOI:10.1016/j.tetlet.2013.04.118

Reference yield:

3,5-difluorobromobenzene (461-96-1) → C11H13F2I (147437-93-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: magnesium / tetrahydrofuran / 1 h / Inert atmosphere; Reflux

1.2: 48 h / Reflux; Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran / -70 °C

2.2: -70 °C

With n-butyllithium; magnesium; In tetrahydrofuran;

DOI:10.1016/j.tetlet.2013.04.118

Reference yield:

amyl iodide (628-17-1) → C11H13F2I (147437-93-2)

Guidance literature:

Multi-step reaction with 2 steps

1: magnesium / tetrahydrofuran

2: tetrahydrofuran / -70 °C / Alkaline conditions

With magnesium; In tetrahydrofuran;

DOI:10.1039/c6ra16023a

upstream raw materials:

3,5-difluoro-1-pentylbenzene

1-Bromopentane

3,5-difluorobromobenzene

amyl iodide

Downstream raw materials:

4'S-[2,6-difluoro-4-pentylphenyl]ethynyl-4'-(2-methyl-1-butyl)biphenyl

Refernces

• 1、 Herman, Jakub,Kula, Przemys?aw. "The synthesis of chiral fluorinated 4-alkyl-4′-[(4-alkylphenyl) ethynyl]biphenyls". . p. 3621 - 3623. Retrieved 2013/07/05.