[(+)-(S)-5'-chloro-1-(5-chloro-2-fluorobenzyl)-3-ethyl-2,2',5-trioxospiro[imidazolidine-4,3'-indol]-1'(2'H)-yl]acetic acid tert-butyl ester

Base Information

Chemical Name:[(+)-(S)-5'-chloro-1-(5-chloro-2-fluorobenzyl)-3-ethyl-2,2',5-trioxospiro[imidazolidine-4,3'-indol]-1'(2'H)-yl]acetic acid tert-butyl ester
CAS No.:1312014-73-5
Molecular Formula:C₂₅H₂₄Cl₂FN₃O₅
Molecular Weight:536.387
Hs Code.:

Synonyms:

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Chemical Property of [(+)-(S)-5'-chloro-1-(5-chloro-2-fluorobenzyl)-3-ethyl-2,2',5-trioxospiro[imidazolidine-4,3'-indol]-1'(2'H)-yl]acetic acid tert-butyl ester

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Technology Process of [(+)-(S)-5'-chloro-1-(5-chloro-2-fluorobenzyl)-3-ethyl-2,2',5-trioxospiro[imidazolidine-4,3'-indol]-1'(2'H)-yl]acetic acid tert-butyl ester

There total 8 articles about [(+)-(S)-5'-chloro-1-(5-chloro-2-fluorobenzyl)-3-ethyl-2,2',5-trioxospiro[imidazolidine-4,3'-indol]-1'(2'H)-yl]acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312296-22-2
(+)-(S)-tert-butyl [5'-chloro-1-(5-chloro-2-fluorobenzyl)-2,2',5-trioxospiro[imidazolidine-4,3'-indol]-1'(2'H)-yl]acetate

: 75-03-6
ethyl iodide

: 1312014-73-5
[(+)-(S)-5'-chloro-1-(5-chloro-2-fluorobenzyl)-3-ethyl-2,2',5-trioxospiro[imidazolidine-4,3'-indol]-1'(2'H)-yl]acetic acid tert-butyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 3h;
DOI:10.1021/ml2001196

Reference yield:

: [5'-chloro-1-(5-chloro-2-fluorobenzyl)-2,2',5-trioxospiro[imidazolidine-4,3'-indol]-1'(2'H)-yl]acetic acid

: 1312014-73-5
[(+)-(S)-5'-chloro-1-(5-chloro-2-fluorobenzyl)-3-ethyl-2,2',5-trioxospiro[imidazolidine-4,3'-indol]-1'(2'H)-yl]acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / methanol / Resolution of racemate; HPLC conditions

2: tetrahydrofuran; dichloromethane / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

With potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ml2001196

Reference yield:

: 916048-05-0
tert-butyl (5-chloro-2,3-dioxo-2,3-dihydro-1H-indol-1-yl)acetate

: 1312014-73-5
[(+)-(S)-5'-chloro-1-(5-chloro-2-fluorobenzyl)-3-ethyl-2,2',5-trioxospiro[imidazolidine-4,3'-indol]-1'(2'H)-yl]acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: water / ethanol / 1.5 h / Reflux

1.2: 1 h / 0 - 5 °C / pH 5

2.1: potassium carbonate / N,N-dimethyl-formamide / 2.25 h / 0 - 20 °C

2.2: 1 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 4 h / 0 - 20 °C

4.1: trifluoroacetic acid / methanol / Resolution of racemate; HPLC conditions

5.1: tetrahydrofuran; dichloromethane / 20 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

With water; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ml2001196