diethyl 4-(4-methoxyphenyl)-2,6-dimethyl-pyridine-3,5-dicarboxylate

Base Information

• Chemical Name: diethyl 4-(4-methoxyphenyl)-2,6-dimethyl-pyridine-3,5-dicarboxylate
• CAS No.: 5448-05-5
• Molecular Formula: C20H23 N O5
• Molecular Weight: 357.406
• Mol file: 5448-05-5.mol

Synonyms:3,5-Pyridinedicarboxylicacid, 4-(4-methoxyphenyl)-2,6-dimethyl-, diethyl ester (9CI);3,5-Pyridinedicarboxylic acid, 4-(p-methoxyphenyl)-2,6-dimethyl-, diethyl ester(7CI,8CI); 4-(4-Methoxyphenyl)-2,6-dimethyl-3,5-pyridinedicarboxylic aciddiethyl ester; Diethyl4-(4-methoxyphenyl)-2,6-dimethyl-3,5-pyridinedicarboxylate; NSC 17355

Chemical Property of diethyl 4-(4-methoxyphenyl)-2,6-dimethyl-pyridine-3,5-dicarboxylate

Chemical Property:

• Vapor Pressure: 2.45E-08mmHg at 25°C
• Melting Point: 50 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 451.4°Cat760mmHg
• PKA: 3.41±0.28(Predicted)
• Flash Point: 226.8°C
• Density: 1.14g/cm³

Purity/Quality:

DIETHYL-4-(4-METHOXYPHENYL)-2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of diethyl 4-(4-methoxyphenyl)-2,6-dimethyl-pyridine-3,5-dicarboxylate

There total 18 articles about diethyl 4-(4-methoxyphenyl)-2,6-dimethyl-pyridine-3,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

diethyl 1,4-dihydro-2,6-dimethyl-4-(4-methoxyphenyl)pyridine-3,5-dicarboxylate (34014-60-3) → diethyl 4-(4-methoxyphenyl)-2,6-dimethylpyridine-3,5-dicarboxylate (5448-05-5)

Guidance literature:

In tetrachloromethane; for 3h; Ambient temperature; Irradiation;

DOI:10.1039/a807093h

Reference yield: 100.0%

4-(4-methoxy-phenyl)-2,6-dimethyl-piperidine-3,5-dicarboxylic acid diethyl ester → diethyl 4-(4-methoxyphenyl)-2,6-dimethylpyridine-3,5-dicarboxylate (5448-05-5)

Guidance literature:

With bis(trimethylsilyl)chromate; In dichloromethane; for 2h; Heating;

DOI:10.1080/00397910500330189

Reference yield: 94.0%

ethyl acetoacetate (141-97-9) + 4-methoxy-benzaldehyde (123-11-5) → diethyl 4-(4-methoxyphenyl)-2,6-dimethylpyridine-3,5-dicarboxylate (5448-05-5)

Guidance literature:

With ammonium chlorate; at 80 ℃; for 0.666667h; Neat (no solvent);

DOI:10.1002/jhet.175

upstream raw materials:

diethyl 1,4-dihydro-2,6-dimethyl-4-(4-methoxyphenyl)pyridine-3,5-dicarboxylate

ethyl acetoacetate

4-methoxy-benzaldehyde

ethyl aminocrotonate

Downstream raw materials:

4-(4-methoxy-phenyl)-2,6-dimethyl-pyridine-3,5-dicarboxylic acid

4-(4-methoxy-phenyl)-2,6-dimethyl-pyridine-3,5-dicarboxylic acid monoethyl ester

4-(4-methoxy-phenyl)-2,6-dimethyl-nicotinic acid

4-(4-methoxy-phenyl)-2,6-dimethyl-nicotinic acid ethyl ester