(S)-1-(Pyridin-3-yl)ethanamine hydrochloride

Base Information

• Chemical Name: (S)-1-(Pyridin-3-yl)ethanamine hydrochloride
• CAS No.: 40154-84-5
• Molecular Formula: C₇H₁₀N₂*ClH
• Molecular Weight: 158.631
• Mol file: 40154-84-5.mol

Synonyms:1391360-97-6;(S)-1-(Pyridin-3-yl)ethanamine hydrochloride;(S)-1-(Pyridin-3-yl)ethanamine DiHCl;(S)-1-(Pyridin-3-yl)ethanaminehydrochloride;s11132;CS-0337455;(S)-1-(PYRIDIN-3-YL)ETHANAMINE HCL;(S)-1-(pyridin-3-yl)ethan-1-amine hydrochloride

Chemical Property of (S)-1-(Pyridin-3-yl)ethanamine hydrochloride

Chemical Property:

• Storage Temp.: Sealed in dry,Room Temperature
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 158.0610761
• Heavy Atom Count: 10
• Complexity: 83

Purity/Quality:

97% ^*data from raw suppliers

(S)-1-(Pyridin-3-yl)ethanaminedihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C1=CN=CC=C1)N.Cl
• Isomeric SMILES: C[C@@H](C1=CN=CC=C1)N.Cl

Technology Process of (S)-1-(Pyridin-3-yl)ethanamine hydrochloride

There total 6 articles about (S)-1-(Pyridin-3-yl)ethanamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(RS,S)-N-[1-(pyridin-3-yl)ethyl]-2-methylpropane-2-sulfinamide → (S)-1-(pyridin-3-yl)ethan-1-amine hydrochloride (40154-84-5,40154-79-8,1391360-97-6)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 1h;

Reference yield:

(1S)-1-(pyridin-3-yl)ethan-1-amine (27854-93-9) → (S)-1-(pyridin-3-yl)ethan-1-amine hydrochloride (40154-84-5,40154-79-8,1391360-97-6)

Guidance literature:

With hydrogenchloride; In methanol; diethyl ether; at 20 - 30 ℃; for 3.33h;

DOI:10.1002/0471264229.os087.05

Reference yield:

methyl-3-pyridylketone (350-03-8) → (S)-1-(pyridin-3-yl)ethan-1-amine hydrochloride (40154-84-5,40154-79-8,1391360-97-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: hydroxylamine hydrochloride; sodium carbonate / ethanol; water / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.75 h / -15 - -10 °C / Inert atmosphere

2.2: -12 - -10 °C / Inert atmosphere

3.1: 1-[([1,3,2]dioxaborolan-2-yloxy)-diphenyl-methyl]-2-methylpropylamine; borane-THF / 1,4-dioxane / 30 h / 0 - 3 °C / Molecular sieve; Inert atmosphere

3.2: 15 h / Reflux; Inert atmosphere

4.1: hydrogenchloride / methanol; diethyl ether / 3.33 h / 20 - 30 °C

With hydrogenchloride; borane-THF; 1-[([1,3,2]dioxaborolan-2-yloxy)-diphenyl-methyl]-2-methylpropylamine; hydroxylamine hydrochloride; sodium hydride; sodium carbonate; In 1,4-dioxane; methanol; diethyl ether; ethanol; water; N,N-dimethyl-formamide; mineral oil;

DOI:10.1002/0471264229.os087.05

upstream raw materials:

methyl-3-pyridylketone

(E)-1-(pyridin-3-yl)ethanone oxime

(E)-1-(pyridin-3-yl)ethanone O-benzyl oxime

(1S)-1-(pyridin-3-yl)ethan-1-amine