Technology Process of 1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-(2,4,5-trimethoxybenzyl)isoquinoline
There total 7 articles about 1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-(2,4,5-trimethoxybenzyl)isoquinoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
In
water; acetic acid;
for 4h;
Heating;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: dimethylsulfoxide / 3 h / 50 - 60 °C
2: 2.8 g / 10 percent NaOH / H2O; ethanol / 6 h / Heating
3: 85 percent / 4 h / 190 - 200 °C
4: 1.) POCl3; 2.) NaBH4 / 1.) benzene, 2 h, reflux; 2.) methanol, 1 h, RT
5: 70 percent / H2O; acetic acid / 4 h / Heating
With
sodium hydroxide; sodium tetrahydroborate; trichlorophosphate;
In
ethanol; water; acetic acid; dimethyl sulfoxide;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: NaBH4 / ethanol / 1 h / Ambient temperature
2: thionyl chloride / CHCl3 / 2 h / Ambient temperature
3: dimethylsulfoxide / 3 h / 50 - 60 °C
4: 2.8 g / 10 percent NaOH / H2O; ethanol / 6 h / Heating
5: 85 percent / 4 h / 190 - 200 °C
6: 1.) POCl3; 2.) NaBH4 / 1.) benzene, 2 h, reflux; 2.) methanol, 1 h, RT
7: 70 percent / H2O; acetic acid / 4 h / Heating
With
sodium hydroxide; sodium tetrahydroborate; thionyl chloride; trichlorophosphate;
In
ethanol; chloroform; water; acetic acid; dimethyl sulfoxide;
