(5,6-Dihydro-[1,4]dioxin-2-yl)-(4-methoxy-phenyl)-methanol

Base Information

• Chemical Name: (5,6-Dihydro-[1,4]dioxin-2-yl)-(4-methoxy-phenyl)-methanol
• CAS No.: 101823-08-9
• Molecular Formula: C₁₂H₁₄O₄
• Molecular Weight: 222.241
• Mol file: 101823-08-9.mol

Synonyms:

Chemical Property of (5,6-Dihydro-[1,4]dioxin-2-yl)-(4-methoxy-phenyl)-methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (5,6-Dihydro-[1,4]dioxin-2-yl)-(4-methoxy-phenyl)-methanol

There total 1 articles about (5,6-Dihydro-[1,4]dioxin-2-yl)-(4-methoxy-phenyl)-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,4-dioxene (543-75-9) + 4-methoxy-benzaldehyde (123-11-5) → (5,6-Dihydro-[1,4]dioxin-2-yl)-(4-methoxy-phenyl)-methanol (101823-08-9)

Guidance literature:

With tert.-butyl lithium; Yield given. Multistep reaction; 1.)THF, -30 deg C; 2.) 2h, -20 grad C;

DOI:10.1016/S0040-4039(00)98662-3

Reference yield:

(5,6-Dihydro-[1,4]dioxin-2-yl)-(4-methoxy-phenyl)-methanol (101823-08-9) → (Z)-2-(2-Hydroxy-ethoxy)-3-(4-methoxy-phenyl)-propenal

Guidance literature:

With oxalic acid; silica gel; sodium hydrogencarbonate; In dichloromethane;

DOI:10.1016/S0040-4039(00)98662-3

Reference yield:

(5,6-Dihydro-[1,4]dioxin-2-yl)-(4-methoxy-phenyl)-methanol (101823-08-9) → 1-Hydroxy-3-(4-methoxyphenyl)-aceton (30095-45-5)

Guidance literature:

Multi-step reaction with 2 steps

1: silica gel, 5percent aqueous solution of oxalic acid, sodium hydrogenocarbonate / CH₂Cl₂

2: LiAlH₄ / 1.) THF, 10 min; 2.) acidic hydrolisis

With lithium aluminium tetrahydride; oxalic acid; silica gel; sodium hydrogencarbonate; In dichloromethane;

DOI:10.1016/S0040-4039(00)98662-3

upstream raw materials:

1,4-dioxene

4-methoxy-benzaldehyde

Downstream raw materials:

1-Hydroxy-3-(4-methoxyphenyl)-aceton