Technology Process of 2,2-Dimethyl-propionic acid (4S,5R)-4,6-bis-benzyloxy-5-hydroxy-hexyl ester
There total 3 articles about 2,2-Dimethyl-propionic acid (4S,5R)-4,6-bis-benzyloxy-5-hydroxy-hexyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) Et3N, 2.) H2, 3.) NaH / 2.) Pd/C / 1.) MeOH, H2O, room temperature, 18 h, 2.) AcOEt, room temperature, 3.) DMF, overnight
2: 1.) AcOH, aq. HCl, 2.) NaBH4 / 1.) reflux, 3 h, 2.) MeOH, 0 deg C, 2 h
3: pyridine / CH2Cl2 / 24 h
With
pyridine; hydrogenchloride; sodium tetrahydroborate; hydrogen; sodium hydride; acetic acid; triethylamine;
palladium on activated charcoal;
In
dichloromethane;
DOI:10.1021/jo9822380
- Guidance literature:
-
Multi-step reaction with 4 steps
1: BF3*OEt2 / benzene / 2.5 h / 35 °C
2: 1.) Et3N, 2.) H2, 3.) NaH / 2.) Pd/C / 1.) MeOH, H2O, room temperature, 18 h, 2.) AcOEt, room temperature, 3.) DMF, overnight
3: 1.) AcOH, aq. HCl, 2.) NaBH4 / 1.) reflux, 3 h, 2.) MeOH, 0 deg C, 2 h
4: pyridine / CH2Cl2 / 24 h
With
pyridine; hydrogenchloride; sodium tetrahydroborate; boron trifluoride diethyl etherate; hydrogen; sodium hydride; acetic acid; triethylamine;
palladium on activated charcoal;
In
dichloromethane; benzene;
DOI:10.1021/jo9822380
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1.) AcOH, aq. HCl, 2.) NaBH4 / 1.) reflux, 3 h, 2.) MeOH, 0 deg C, 2 h
2: pyridine / CH2Cl2 / 24 h
With
pyridine; hydrogenchloride; sodium tetrahydroborate; acetic acid;
In
dichloromethane;
DOI:10.1021/jo9822380
