(2R,3S,6S)-6-ethoxy-3-phenylmethoxy-2-phenylmethoxymethyltetrahydropyran

Base Information

Chemical Name:(2R,3S,6S)-6-ethoxy-3-phenylmethoxy-2-phenylmethoxymethyltetrahydropyran
CAS No.:104784-32-9
Molecular Formula:C₂₂H₂₈O₄
Molecular Weight:356.462
Hs Code.:

Synonyms:(2R,3S,6S)-6-ethoxy-3-phenylmethoxy-2-phenylmethoxymethyltetrahydropyran

Suppliers and Price of (2R,3S,6S)-6-ethoxy-3-phenylmethoxy-2-phenylmethoxymethyltetrahydropyran

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (2R,3S,6S)-6-ethoxy-3-phenylmethoxy-2-phenylmethoxymethyltetrahydropyran

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Technology Process of (2R,3S,6S)-6-ethoxy-3-phenylmethoxy-2-phenylmethoxymethyltetrahydropyran

There total 4 articles about (2R,3S,6S)-6-ethoxy-3-phenylmethoxy-2-phenylmethoxymethyltetrahydropyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 100-39-0
benzyl bromide

: 23339-16-4
(2R,3S,6S)-6-ethoxy-2-(hydroxymethyl)tetrahydro-2H-pyran-3-ol

: 104784-32-9
(2R,3S,6S)-6-ethoxy-3-phenylmethoxy-2-phenylmethoxymethyltetrahydropyran

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 20 - 25 ℃; for 16h;
DOI:10.1016/S0957-4166(00)80289-X

Reference yield:

: 2873-29-2
D-glucal triacetate

: 104784-32-9
(2R,3S,6S)-6-ethoxy-3-phenylmethoxy-2-phenylmethoxymethyltetrahydropyran

Guidance literature:: Multi-step reaction with 2 steps

1: BF₃*OEt₂ / benzene / 2.5 h / 35 °C

2: 1.) Et₃N, 2.) H₂, 3.) NaH / 2.) Pd/C / 1.) MeOH, H₂O, room temperature, 18 h, 2.) AcOEt, room temperature, 3.) DMF, overnight

With boron trifluoride diethyl etherate; hydrogen; sodium hydride; triethylamine; palladium on activated charcoal; In benzene;
DOI:10.1021/jo9822380

Reference yield:

: 100-39-0
benzyl bromide

: 3323-72-6
ethyl 4,6-di-O-acetyl-2,3-dideoxy-α-D-erythrohex-2-enopyranoside

: 104784-32-9
(2R,3S,6S)-6-ethoxy-3-phenylmethoxy-2-phenylmethoxymethyltetrahydropyran

Guidance literature:: With hydrogen; sodium hydride; triethylamine; palladium on activated charcoal; Yield given; Multistep reaction; 1.) MeOH, H₂O, room temperature, 18 h, 2.) AcOEt, room temperature, 3.) DMF, overnight;
DOI:10.1021/jo9822380