104784-32-9Relevant academic research and scientific papers
Radical-mediated construction of cyclopentane with concurrent formation of a well-defined quaternary center
Zhu,Qiao,Wu,Wu
, p. 2428 - 2432 (2007/10/03)
Synthetic efforts toward the total synthesis of clavulactone dealing with enantioselective construction of the cyclopentane moiety are reported. With a novel radical-mediated cyclization as key step, the current approach allows for concurrent enantioselective construction of a quaternary chiral carbon at the cyclization step. The stereochemistries of the newly formed chiral centers are dictated by the configuration of the C-1 (cf. numbering in 1). The high selectivity observed in this work is ascribed to the conformational advantage of the cyclic acetal, which results in a much better defined transition state than the previously used open-chain counterpart does.
SYNTHESIS OF (S)- AND (R)-3--2,2-DIFLUOROTETRADECANOIC ACID
Shiozaki, Masao,Kobayashi, Yoshiyuki
, p. 451 - 458 (2007/10/02)
Optically active 3--2,2-difluorotetradecanoic acids, (S)-11 and (R)-22 were synthesized from 3,4,6-tri-O-acetyl-D-glucal and methyl galactopyranoside via 4 and 15, respectively.Reaction of 4 and 15 with octylidene triphenylphosphor
ENANTIOSPECIFIC SYNTHESIS OF (R)-(+)-α-LIPOIC ACID FROM D-GLUCOSE
Rao, A. V. Rama,Gurjar, Mukund K.,Garyali, Kamini,Ravindranathan, T.
, p. 51 - 56 (2007/10/02)
The first enantiospecific synthesis of natural (R)-(+)-α-lipoic acid in 13 steps starting from D-glucose is described.
