C₃₇H₃₃ClF₂N₈O₃

Base Information

• Chemical Name: C₃₇H₃₃ClF₂N₈O₃
• CAS No.: 1430562-67-6
• Molecular Formula: C₃₇H₃₃ClF₂N₈O₃
• Molecular Weight: 711.171
• Mol file: 1430562-67-6.mol

Synonyms:

Chemical Property of C₃₇H₃₃ClF₂N₈O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₇H₃₃ClF₂N₈O₃

There total 5 articles about C₃₇H₃₃ClF₂N₈O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-fluorophenyl isocyanide (24075-34-1) + (E)-3-(5-chloro-4-fluoro-2-(1H-tetrazol-1-yl)phenyl)acrylic acid (1430115-37-9) + C20H23N3O → C37H33ClF2N8O3 (1430562-67-6)

Guidance literature:

In ethanol; for 24h; Reflux;

Reference yield:

4-chloro-5-fluoro-2-iodo-phenylamine (1094759-93-9) → C37H33ClF2N8O3 (1430562-67-6)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium azide; acetic acid / 30 h

2: palladium diacetate; triethylamine / acetonitrile / 18 h / 85 °C / Inert atmosphere

3: sodium hydroxide; methanol / tetrahydrofuran / 2 h

4: ethanol / 24 h / Reflux

With methanol; sodium azide; palladium diacetate; acetic acid; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; acetonitrile; 4: |Ugi Condensation;

Reference yield:

4-chloro-3-fluoroaniline (367-22-6) → C37H33ClF2N8O3 (1430562-67-6)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium hydrogencarbonate; iodine / water / 0 - 20 °C

2: sodium azide; acetic acid / 30 h

3: palladium diacetate; triethylamine / acetonitrile / 18 h / 85 °C / Inert atmosphere

4: sodium hydroxide; methanol / tetrahydrofuran / 2 h

5: ethanol / 24 h / Reflux

With methanol; sodium azide; iodine; palladium diacetate; sodium hydrogencarbonate; acetic acid; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; water; acetonitrile; 5: |Ugi Condensation;

upstream raw materials:

4-chloro-5-fluoro-2-iodo-phenylamine

4-chloro-3-fluoroaniline

1-(4-chloro-5-fluoro-2-iodophenyl)-1H-tetrazole

(E)-methyl 3-(5-chloro-4-fluoro-2-(1H-tetrazol-1-yl)phenyl)acrylate