Technology Process of 3,5,5-triethyl-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylic acid
There total 9 articles about 3,5,5-triethyl-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
5,5-diethyl-4,5,6,7-tetrahydro-benzo[c]thiophene-1-carboxylic acid;
With
tert.-butyl lithium;
In
tetrahydrofuran; pentane;
at -78 ℃;
for 0.166667h;
ethyl iodide;
In
tetrahydrofuran; pentane;
at -78 ℃;
for 3h;
DOI:10.1021/jm401456d
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: sulfuric acid / 40 °C
2.1: hydrogen; palladium 10% on activated carbon / ethyl acetate / 24 h / 20 °C / 750.08 Torr
3.1: potassium tert-butylate / tetrahydrofuran / 18 h / 20 °C
4.1: oxalyl dichloride / chloroform / 1 h / 20 °C
5.1: sodium ethanolate / tetrahydrofuran; ethanol / 2 h / 20 °C
6.1: sodium ethanolate / ethanol / 18 h / 20 - 60 °C
7.1: water; lithium hydroxide / ethanol / 70 °C
8.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.17 h / -78 °C
8.2: 3 h / -78 °C
With
oxalyl dichloride; sulfuric acid; palladium 10% on activated carbon; potassium tert-butylate; water; hydrogen; tert.-butyl lithium; sodium ethanolate; lithium hydroxide;
In
tetrahydrofuran; ethanol; chloroform; ethyl acetate; pentane;
DOI:10.1021/jm401456d
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: hydrogen; palladium 10% on activated carbon / ethyl acetate / 24 h / 20 °C / 750.08 Torr
2.1: potassium tert-butylate / tetrahydrofuran / 18 h / 20 °C
3.1: oxalyl dichloride / chloroform / 1 h / 20 °C
4.1: sodium ethanolate / tetrahydrofuran; ethanol / 2 h / 20 °C
5.1: sodium ethanolate / ethanol / 18 h / 20 - 60 °C
6.1: water; lithium hydroxide / ethanol / 70 °C
7.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.17 h / -78 °C
7.2: 3 h / -78 °C
With
oxalyl dichloride; palladium 10% on activated carbon; potassium tert-butylate; water; hydrogen; tert.-butyl lithium; sodium ethanolate; lithium hydroxide;
In
tetrahydrofuran; ethanol; chloroform; ethyl acetate; pentane;
DOI:10.1021/jm401456d
![5,5-diethyl-4,5,6,7-tetrahydro-benzo[c]thiophene-1-carboxylic acid](/Databaselist/images/loading.webp)
