3-p-methoxyphenyl-2-carboxy-4-phenylbutyric acid

Base Information

• Chemical Name: 3-p-methoxyphenyl-2-carboxy-4-phenylbutyric acid
• CAS No.: 118806-75-0
• Molecular Formula: C₁₈H₁₈O₅
• Molecular Weight: 314.338
• Mol file: 118806-75-0.mol

Synonyms:

Chemical Property of 3-p-methoxyphenyl-2-carboxy-4-phenylbutyric acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-p-methoxyphenyl-2-carboxy-4-phenylbutyric acid

There total 6 articles about 3-p-methoxyphenyl-2-carboxy-4-phenylbutyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C20H22O5 (1333110-92-1) → 3-p-methoxyphenyl-2-carboxy-4-phenylbutyric acid (118806-75-0)

Guidance literature:

With potassium hydroxide; In water; for 3h; Reflux;

DOI:10.1007/s12039-010-0071-2

Reference yield:

4-methoxy-benzaldehyde (123-11-5) → 3-p-methoxyphenyl-2-carboxy-4-phenylbutyric acid (118806-75-0)

Guidance literature:

Multi-step reaction with 3 steps

1: pyrrolidine; acetic acid / toluene / 3 h / Reflux

2: copper(l) chloride / tetrahydrofuran / 1 h / 0 °C

3: potassium hydroxide / water / 3 h / Reflux

With pyrrolidine; acetic acid; copper(l) chloride; potassium hydroxide; In tetrahydrofuran; water; toluene; 1: Knoevenagel condensation;

DOI:10.1007/s12039-010-0071-2

Reference yield:

dimethyl 2-(4-methoxybenzylidene)malonate (7443-25-6) → 3-p-methoxyphenyl-2-carboxy-4-phenylbutyric acid (118806-75-0)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(l) chloride / tetrahydrofuran / 1 h / 0 °C

2: potassium hydroxide / water / 3 h / Reflux

With copper(l) chloride; potassium hydroxide; In tetrahydrofuran; water;

DOI:10.1007/s12039-010-0071-2

upstream raw materials:

diethyl-2-(4-methoxybenzylidene)malonate

4-methoxy-benzaldehyde

C₂₀H₂₂O₅

dimethyl 2-(4-methoxybenzylidene)malonate

Downstream raw materials:

cis-4-hydroxy-3-[1,2,3,4-tetrahydro-3-[4-(4-trifluoromethylbenzyloxy)phenyl]-1-naphthyl]coumarin

trans-4-hydroxy-3-[1,2,3,4-tetrahydro-3-[4-(4-trifluoromethylbenzyloxy)phenyl]-1-naphthyl]coumarin

3-(4-hydroxyphenyl)-3,4-dihydronaphthalen-1(2H)-one

1,2,3,4-tetrahydro-3-[4-(4-trifluoromethylbenzyloxy)phenyl]naphthalen-1-ol

Refernces

• 1、 Selvaraj, S.,Rajendran, A. S.,Arumugam, N.. "Synthesis of 3-Aryl-1-tetralones". . p. 1047 - 1049. Retrieved 2007/10/02.