Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2,2,2-trichloro-ethyl ester

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Chemical Name:Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2,2,2-trichloro-ethyl ester
CAS No.:103411-65-0
Molecular Formula:C₃₉H₄₇Cl₃N₃O₈P
Molecular Weight:823.15
Hs Code.:

Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2,2,2-trichloro-ethyl ester

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Chemical Property of Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2,2,2-trichloro-ethyl ester

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Technology Process of Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2,2,2-trichloro-ethyl ester

There total 2 articles about Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2,2,2-trichloro-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 108-18-9
diisopropylamine

: 103411-65-0,108865-49-2,108865-52-7
Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2,2,2-trichloro-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 67 percent / PCl₃ / diethyl ether / 1.) -10 grad C, 2.5 h, 2.) room temperature, 1 h

2: 1.) isopropylethylamine / 1.) CH₂Cl₂, -10 grad C, 30 min, 2.) CH₂Cl₂, 30 min

With N-isopropylethylamine; phosphorus trichloride; In diethyl ether;
DOI:10.1016/S0040-4039(00)83976-3

Reference yield:

: 115-20-8
1,1,1-trichloroethanol

: 921-26-6
N,N-diisopropylphosphoramide dichloride

: 40615-39-2
5'-O-(4-4'-dimethoxytrityl)thymidine

: 103411-65-0,108865-49-2,108865-52-7
Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2,2,2-trichloro-ethyl ester

Guidance literature:: With N-isopropylethylamine; Yield given. Multistep reaction; 1.) CH₂Cl₂, -10 grad C, 30 min, 2.) CH₂Cl₂, 30 min;
DOI:10.1016/S0040-4039(00)83976-3