(1R,2R)-3--1-hydroxy-2-methanesulfonyloxy-1-phenylpropane

Base Information

Chemical Name:(1R,2R)-3--1-hydroxy-2-methanesulfonyloxy-1-phenylpropane
CAS No.:223394-11-4
Molecular Formula:C₂₂H₂₇NO₅S
Molecular Weight:417.526
Hs Code.:

(1R,2R)-3-<N-(benzoyl)piperidin-4-yl>-1-hydroxy-2-methanesulfonyloxy-1-phenylpropane

Synonyms:

Suppliers and Price of (1R,2R)-3--1-hydroxy-2-methanesulfonyloxy-1-phenylpropane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1R,2R)-3--1-hydroxy-2-methanesulfonyloxy-1-phenylpropane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1R,2R)-3--1-hydroxy-2-methanesulfonyloxy-1-phenylpropane

There total 11 articles about (1R,2R)-3--1-hydroxy-2-methanesulfonyloxy-1-phenylpropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 124-63-0
methanesulfonyl chloride

: 223393-98-4
(1R,2R)-3--1,2-dihydroxy-1-phenylpropane

: 223394-11-4
(1R,2R)-3--1-hydroxy-2-methanesulfonyloxy-1-phenylpropane

: Methanesulfonic acid (1R,2R)-1-(1-benzoyl-piperidin-4-ylmethyl)-2-methanesulfonyloxy-2-phenyl-ethyl ester

Guidance literature:: In pyridine; at -20 ℃; for 24h;
DOI:10.1016/S0040-4020(99)00050-2

Reference yield:

: 5344-27-4
4-(2-hydroxyethyl)pyridine

: 223394-11-4
(1R,2R)-3--1-hydroxy-2-methanesulfonyloxy-1-phenylpropane

Guidance literature:: Multi-step reaction with 7 steps

1: 100 percent / H₂, conc. HCl / Pt/C / H₂O / 264 h / Ambient temperature

2: 98 percent / 4M NaOH / Ambient temperature

3: (COCl)2, DMSO, Et₃N / tetrahydrofuran / 0.5 h / -35 - 20 °C

4: 1.) nBuLi / 1.) THF, hexane, room temperature, 30 min, 2.) -78 deg C -> room temperature, 1 h

5: I₂ / CHCl₃ / 192 h / Irradiation

6: 72 percent / Ad-mix-β, CH3SO2NH2 / 2-methyl-propan-2-ol; H2O / 1.) 0 deg C, 7 h, 2.) room temperature, 17 h

7: 69 percent / pyridine / 24 h / -20 °C

With hydrogenchloride; sodium hydroxide; n-butyllithium; oxalyl dichloride; methanesulfonamide; AD-mix-β; hydrogen; iodine; dimethyl sulfoxide; triethylamine; platinum on activated charcoal; In tetrahydrofuran; pyridine; chloroform; water; tert-butyl alcohol;
DOI:10.1016/S0040-4020(99)00050-2

Reference yield:

: 152902-80-2
(4-(2-hydroxyethyl)piperidin-1-yl)(phenyl)methanone

: 223394-11-4
(1R,2R)-3--1-hydroxy-2-methanesulfonyloxy-1-phenylpropane

Guidance literature:: Multi-step reaction with 5 steps

1: (COCl)2, DMSO, Et₃N / tetrahydrofuran / 0.5 h / -35 - 20 °C

2: 1.) nBuLi / 1.) THF, hexane, room temperature, 30 min, 2.) -78 deg C -> room temperature, 1 h

3: I₂ / CHCl₃ / 192 h / Irradiation

4: 72 percent / Ad-mix-β, CH3SO2NH2 / 2-methyl-propan-2-ol; H2O / 1.) 0 deg C, 7 h, 2.) room temperature, 17 h

5: 69 percent / pyridine / 24 h / -20 °C

With n-butyllithium; oxalyl dichloride; methanesulfonamide; AD-mix-β; iodine; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; pyridine; chloroform; water; tert-butyl alcohol;
DOI:10.1016/S0040-4020(99)00050-2