2-((6-methoxy-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methyl)-7-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:2-((6-methoxy-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methyl)-7-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline
CAS No.:1610624-89-9
Molecular Formula:C₂₅H₂₃F₃N₄O
Molecular Weight:452.479
Hs Code.:

Synonyms:

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Chemical Property of 2-((6-methoxy-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methyl)-7-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline

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Technology Process of 2-((6-methoxy-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methyl)-7-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline

There total 9 articles about 2-((6-methoxy-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methyl)-7-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-63-0
phenylhydrazine

: 1610624-89-9
2-((6-methoxy-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methyl)-7-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 9 steps

1.1: acetic acid / 100 °C

2.1: trichlorophosphate / 70 °C

3.1: sodium azide; tetra(n-butyl)ammonium hydrogensulfate / dimethyl sulfoxide

4.1: sodium dithionite / methanol

5.1: 8 h / 160 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere

6.2: 16 h / 0 - 20 °C / Inert atmosphere

7.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C

8.1: phosphorus tribromide / dichloromethane / 1 h / 0 - 20 °C

9.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / Inert atmosphere

With lithium aluminium tetrahydride; sodium azide; sodium dithionite; tetra(n-butyl)ammonium hydrogensulfate; phosphorus tribromide; potassium carbonate; acetic acid; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm5002937

Reference yield:

: 89-25-8
edaravone

: 1610624-89-9
2-((6-methoxy-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methyl)-7-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 8 steps

1.1: trichlorophosphate / 70 °C

2.1: sodium azide; tetra(n-butyl)ammonium hydrogensulfate / dimethyl sulfoxide

3.1: sodium dithionite / methanol

4.1: 8 h / 160 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere

5.2: 16 h / 0 - 20 °C / Inert atmosphere

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C

7.1: phosphorus tribromide / dichloromethane / 1 h / 0 - 20 °C

8.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / Inert atmosphere

With lithium aluminium tetrahydride; sodium azide; sodium dithionite; tetra(n-butyl)ammonium hydrogensulfate; phosphorus tribromide; potassium carbonate; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm5002937

Reference yield:

: 947-95-5
5-chloro-4-formyl-3-methyl-1-phenyl-1H-pyrazole

: 1610624-89-9
2-((6-methoxy-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methyl)-7-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium azide; tetra(n-butyl)ammonium hydrogensulfate / dimethyl sulfoxide

2.1: sodium dithionite / methanol

3.1: 8 h / 160 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere

4.2: 16 h / 0 - 20 °C / Inert atmosphere

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C

6.1: phosphorus tribromide / dichloromethane / 1 h / 0 - 20 °C

7.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / Inert atmosphere

With lithium aluminium tetrahydride; sodium azide; sodium dithionite; tetra(n-butyl)ammonium hydrogensulfate; phosphorus tribromide; potassium carbonate; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm5002937