1,5-bis(4-(chloromethyl)phenoxy)pentane

Base Information

• Chemical Name: 1,5-bis(4-(chloromethyl)phenoxy)pentane
• CAS No.: 94379-90-5
• Molecular Formula: C₁₉H₂₂Cl₂O₂
• Molecular Weight: 353.288
• Mol file: 94379-90-5.mol

Synonyms:

Chemical Property of 1,5-bis(4-(chloromethyl)phenoxy)pentane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,5-bis(4-(chloromethyl)phenoxy)pentane

There total 5 articles about 1,5-bis(4-(chloromethyl)phenoxy)pentane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

((pentane-1,5-diylbis(oxy))bis(4,1-phenylene))dimethanol (96767-06-5) → 1,5-bis(4-(chloromethyl)phenoxy)pentane (94379-90-5)

Guidance literature:

With tetrachloromethane; triphenylphosphine; Reflux;

DOI:10.1021/jm7010707

Reference yield:

(4-hydroxyphenyl)methanol (623-05-2) → 1,5-bis(4-(chloromethyl)phenoxy)pentane (94379-90-5)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine / N,N-dimethyl-formamide / 4 h / Cooling with ice

2: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

3: potassium hydrogensulfate / water; tetrahydrofuran / 2 h / 50 °C

4: thionyl chloride / dichloromethane / 1.5 h / 0 - 20 °C

With potassium hydrogensulfate; thionyl chloride; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/jm3014585

Reference yield:

4-((tert-butyldimethylsilyloxy)methyl)phenol (126070-20-0) → 1,5-bis(4-(chloromethyl)phenoxy)pentane (94379-90-5)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

2: potassium hydrogensulfate / water; tetrahydrofuran / 2 h / 50 °C

3: thionyl chloride / dichloromethane / 1.5 h / 0 - 20 °C

With potassium hydrogensulfate; thionyl chloride; potassium carbonate; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/jm3014585

upstream raw materials:

((pentane-1,5-diylbis(oxy))bis(4,1-phenylene))dimethanol

(4-hydroxyphenyl)methanol

4-((tert-butyldimethylsilyloxy)methyl)phenol

1,5-bis(4-(((tert-butyldimethylsilyl)oxy)methyl)phenoxy)pentane

Refernces

• 1、 Zhou, Lu,Fang, Chao,Wei, Ping,Liu, Shiyong,Liu, Ying,Lai, Luhua. "Chemically induced dimerization of human nonpancreatic secretory phospholipase A2 by bis-indole derivatives". experimental part. p. 3360 - 3366. Retrieved 2009/04/06.