C₂₇H₂₇N₃O₄S₂

Base Information

• Chemical Name: C₂₇H₂₇N₃O₄S₂
• CAS No.: 1623808-01-4
• Molecular Formula: C₂₇H₂₇N₃O₄S₂
• Molecular Weight: 521.661
• Mol file: 1623808-01-4.mol

Synonyms:

Chemical Property of C₂₇H₂₇N₃O₄S₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₇H₂₇N₃O₄S₂

There total 10 articles about C₂₇H₂₇N₃O₄S₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

C27H26(2)HN5O4S2 (1623807-81-7) → C27H27N3O4S2 (1623808-01-4)

Guidance literature:

With C₃₂H₆₄O₈Rh₂; In ⁽²⁾H₈-toluene; at 80 ℃; for 1.41667h; Time; Kinetics; Inert atmosphere; Schlenk technique;

DOI:10.1002/anie.201400881

Reference yield:

N-(2-(1H-indol-1-yl)ethyl)-4-methyl-N-((1-tosyl-1H-1,2,3-triazol-4-yl)methyl)benzenesulfonamide (1623807-69-1) → C27H27N3O4S2 (1623808-01-4)

Guidance literature:

With C₃₂H₆₄O₈Rh₂; In 1,2-dichloro-ethane; at 80 ℃; Inert atmosphere; Schlenk technique;

DOI:10.1002/anie.201400881

Reference yield:

indole (120-72-9) → C27H27N3O4S2 (1623808-01-4)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium hydroxide / dimethyl sulfoxide / 20 °C / Schlenk technique

2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 24 h / 0 - 20 °C / Schlenk technique

3: copper(I) thiophene-2-carboxylate / toluene / 20 °C / Schlenk technique

4: C₃₂H₆₄O₈Rh₂ / 1,2-dichloro-ethane / 2 h / 80 °C / Inert atmosphere; Schlenk technique

With copper(I) thiophene-2-carboxylate; di-isopropyl azodicarboxylate; C₃₂H₆₄O₈Rh₂; triphenylphosphine; potassium hydroxide; In tetrahydrofuran; dimethyl sulfoxide; 1,2-dichloro-ethane; toluene;

DOI:10.1002/anie.201400881

upstream raw materials:

N-(2-(1H-indol-1-yl)ethyl)-4-methyl-N-((1-tosyl-1H-1,2,3-triazol-4-yl)methyl)benzenesulfonamide

C₂₇H₂₆⁽²⁾HN₅O₄S₂

indole

2-(1H-indol-1-yl)ethanol

Downstream raw materials:

4-methyl-N-((3-tosyl-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,7-a]indol-1-yl)methyl)benzenesulfonamide

4-methyl-N-(prop-2-ynyl)-N-((3-tosyl-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,7-a]indol-1-yl)methyl)benzenesulfonamide

C₃₀H₃₁N₃O₄S₂

C₂₈H₂₉N₃O₄S₂