C₂₁H₂₃F₅NO₅P

Base Information

• Chemical Name: C₂₁H₂₃F₅NO₅P
• CAS No.: 1911578-98-7
• Molecular Formula: C₂₁H₂₃F₅NO₅P
• Molecular Weight: 495.383
• Mol file: 1911578-98-7.mol

Synonyms:

Chemical Property of C₂₁H₂₃F₅NO₅P

Chemical Property:

• Boiling Point: 480.9±55.0 °C(Predicted)
• Density: 1.331±0.06 g/cm3(Predicted)

Purity/Quality:

99%min, ^*data from raw suppliers

2-ethylbutyl(2S)-2-[[(2,3,4,5,6-pentafluorophenoxy)-phenoxyphosphoryl]amino]propanoate 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₂₃F₅NO₅P

There total 10 articles about C₂₁H₂₃F₅NO₅P which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

→ (2S)-2-(((perfluorophenoxy)(phenoxy)phosphoryl)amino)propanoic acid 2-ethylbutyl ester (1911578-98-7)

Guidance literature:

With triethylamine; In dichloromethane; at -70 - 0 ℃; for 4.5h; Inert atmosphere;

With triethylamine; In dichloromethane; at 0 ℃; for 18h; Inert atmosphere;

Reference yield: 87.0%

(2S)-2-(((perfluorophenoxy)(phenoxy)phosphoryl)amino)propanoic acid 2-ethylbutyl ester (1911578-98-7) → C21H23F5NO5P (1911578-98-7)

Guidance literature:

With 1H-imidazole; 2,3,4,5,6-pentafluorophenol; In di-isopropyl ether; at 0 - 5 ℃;

Reference yield: 74.0%

2,3,4,5,6-pentafluorophenol (771-61-9) + 2-ethylbutyl (S)-2-aminopropanoate hydrochloride (946511-97-3) + O-phenyl phosphorodichloridate (770-12-7) → (2S)-2-(((perfluorophenoxy)(phenoxy)phosphoryl)amino)propanoic acid 2-ethylbutyl ester (1911578-98-7)

Guidance literature:

2,3,4,5,6-pentafluorophenol; O-phenyl phosphorodichloridate; With triethylamine; In dichloromethane; at 40 ℃; for 1h;

2-ethylbutyl (S)-2-aminopropanoate hydrochloride; In dichloromethane; for 2h; Temperature; Solvent; Reagent/catalyst;

upstream raw materials:

2,3,4,5,6-pentafluorophenol

2-ethylbutyl (S)-2-aminopropanoate hydrochloride

O-phenyl phosphorodichloridate

2-ethylbutyl (2S)-2-{[chloro(phenoxy)phosphoryl]amino}propanoate

Downstream raw materials:

(2S)-2-ethylbutyl 2-(((S)-(((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate

Refernces

• 1、 -. "Ribavirin side chain intermediate and preparation method thereof (by machine translation)". Paragraph 0047-0057. . Retrieved 2020/07/02.
• 2、 -. "2,4,7-SUBSTITUTED-7-DEAZA-2'-DEOXY-2'-FLUOROARABINOSYL NUCLEOSIDE AND NUCLEOTIDE PRO-DRUGS AND USES THEREOF". Paragraph 00350. . Retrieved 2020/12/30.