Technology Process of α-phenyl-β-(4-methoxy-phenyl)-propyl alcohol
There total 5 articles about α-phenyl-β-(4-methoxy-phenyl)-propyl alcohol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
6b,9a-dimethyl-8-((E)-prop-1-en-1-yl)-6b,9a-dihydroacenaphtho[1,2-d][1,3,2]dioxaborole; phenyllithium;
In
tetrahydrofuran; dibutyl ether;
at 0 - 20 ℃;
for 0.25h;
Inert atmosphere;
Glovebox;
Sealed tube;
4-methoxyphenyl triflate;
With
C64H74FeN2O4P2; palladium diacetate; cesium fluoride;
In
tetrahydrofuran; dibutyl ether;
at 20 ℃;
for 20h;
Inert atmosphere;
Glovebox;
Sealed tube;
With
dihydrogen peroxide; sodium hydroxide;
In
tetrahydrofuran; dibutyl ether; water;
at 0 - 20 ℃;
for 4h;
enantioselective reaction;
Inert atmosphere;
Glovebox;
Sealed tube;
DOI:10.1021/jacs.8b09909
- Guidance literature:
-
With
chlorotriisopropylsilane; 3,5-difluoro-2,4,6-tris(N-phenylanilino)benzonitrile; potassium carbonate;
In
acetonitrile;
at 25 ℃;
for 16h;
Photolysis;
Molecular sieve;
DOI:10.1039/c9sc04987h
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 1H-imidazole; iron(III) chloride / acetonitrile / 1 h / 20 °C / Inert atmosphere
2.1: tetrahydrofuran; dibutyl ether / 0.25 h / 0 - 20 °C / Inert atmosphere; Glovebox; Sealed tube
2.2: 20 h / 20 °C / Inert atmosphere; Glovebox; Sealed tube
2.3: 4 h / 0 - 20 °C / Inert atmosphere; Glovebox; Sealed tube
With
1H-imidazole; iron(III) chloride;
In
tetrahydrofuran; dibutyl ether; acetonitrile;
DOI:10.1021/jacs.8b09909
