Technology Process of (4S,6R)-4-(2-Benzyloxy-ethyl)-6-iodomethyl-[1,3]dioxan-2-one
There total 5 articles about (4S,6R)-4-(2-Benzyloxy-ethyl)-6-iodomethyl-[1,3]dioxan-2-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) MsCl, 2.) Triton B / 1.) pyridine, -60 deg C, 2 h, then room temp., 20 h, 2.) ether, room temp., 1 h
2: 92 percent / tetrahydrofuran / 12 h / Ambient temperature
3: 1.) BuLi, 2.) I2 / 1.) THF, hexane, room temp., 30 min, 2.) 0 deg C, 2 h, then room temp., 30 min
With
n-butyllithium; iodine; N-benzyl-trimethylammonium hydroxide; methanesulfonyl chloride;
In
tetrahydrofuran;
DOI:10.1016/S0040-4039(01)81171-0
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 95 percent / H2O / acetic acid / 1 h / 50 °C
2: 1.) MsCl, 2.) Triton B / 1.) pyridine, -60 deg C, 2 h, then room temp., 20 h, 2.) ether, room temp., 1 h
3: 92 percent / tetrahydrofuran / 12 h / Ambient temperature
4: 1.) BuLi, 2.) I2 / 1.) THF, hexane, room temp., 30 min, 2.) 0 deg C, 2 h, then room temp., 30 min
With
n-butyllithium; water; iodine; N-benzyl-trimethylammonium hydroxide; methanesulfonyl chloride;
In
tetrahydrofuran; acetic acid;
DOI:10.1016/S0040-4039(01)81171-0
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 91 percent / NaH / dimethylformamide / 1.) 0 deg C, 2 h, 2.) room temp., 20 h
2: 95 percent / H2O / acetic acid / 1 h / 50 °C
3: 1.) MsCl, 2.) Triton B / 1.) pyridine, -60 deg C, 2 h, then room temp., 20 h, 2.) ether, room temp., 1 h
4: 92 percent / tetrahydrofuran / 12 h / Ambient temperature
5: 1.) BuLi, 2.) I2 / 1.) THF, hexane, room temp., 30 min, 2.) 0 deg C, 2 h, then room temp., 30 min
With
n-butyllithium; water; iodine; N-benzyl-trimethylammonium hydroxide; sodium hydride; methanesulfonyl chloride;
In
tetrahydrofuran; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(01)81171-0
