2-Methoxy-6-methyl-4-<(E)-prop-1-enyl>phenyl N,N,N',N'-tetramethylphosphorodiamidate

Base Information

• Chemical Name: 2-Methoxy-6-methyl-4-<(E)-prop-1-enyl>phenyl N,N,N',N'-tetramethylphosphorodiamidate
• CAS No.: 133642-18-9
• Molecular Formula: C₁₅H₂₅N₂O₃P
• Molecular Weight: 312.349
• Mol file: 133642-18-9.mol

Synonyms:

Chemical Property of 2-Methoxy-6-methyl-4-<(E)-prop-1-enyl>phenyl N,N,N',N'-tetramethylphosphorodiamidate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Methoxy-6-methyl-4-<(E)-prop-1-enyl>phenyl N,N,N',N'-tetramethylphosphorodiamidate

There total 2 articles about 2-Methoxy-6-methyl-4-<(E)-prop-1-enyl>phenyl N,N,N',N'-tetramethylphosphorodiamidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-2-methoxy-4-(1-propenyl)phenol (5932-68-3) → 2-Methoxy-6-methyl-4-<(E)-prop-1-enyl>phenyl N,N,N',N'-tetramethylphosphorodiamidate (133642-18-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaH / THF

2: 1.) sec-BuLi / 1.) THF, -105 deg C, 2.) THF

With sec.-butyllithium; sodium hydride;

DOI:10.1248/cpb.39.41

Reference yield:

2-Methoxy-4-<(E)-prop-1-enyl>phenyl N,N,N',N'-tetramethylphosphorodiamidate (133642-17-8) + methyl iodide (74-88-4) → 2-Methoxy-6-methyl-4-<(E)-prop-1-enyl>phenyl N,N,N',N'-tetramethylphosphorodiamidate (133642-18-9)

Guidance literature:

With sec.-butyllithium; Yield given. Multistep reaction; 1.) THF, -105 deg C, 2.) THF;

DOI:10.1248/cpb.39.41

Reference yield:

2-Methoxy-6-methyl-4-<(E)-prop-1-enyl>phenyl N,N,N',N'-tetramethylphosphorodiamidate (133642-18-9) → eupomatenoid-1 (23357-64-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) sec-BuLi / 1.) THF, -105 deg C, 2.) THF

2: 1.) sec-BuLi, N,N,N',N'-tetramethylethylenediamine / 1.) THF, -105 deg C, 1 h, 2.) -105 deg C

3: 68 percent / 90 percent formic acid / 0.5 h / Heating

With formic acid; N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium;

DOI:10.1248/cpb.39.41

upstream raw materials:

2-Methoxy-4-<(E)-prop-1-enyl>phenyl N,N,N',N'-tetramethylphosphorodiamidate

methyl iodide

(E)-2-methoxy-4-(1-propenyl)phenol

Downstream raw materials:

2-Ethyl-6-methoxy-4-<(E)-prop-1-enyl>phenyl N,N,N',N'-tetramethylphosphorodiamidate

2-(4-hydroxyphenyl)-7-methoxy-3-methyl-5-(E)-propenylbenzofuran

eupomatenoid-1

C₂₄H₃₁N₂O₆P