Technology Process of 1-((1S,3R,4S)-4-Benzyloxy-3-benzyloxymethyl-2-methylene-cyclopentyl)-5-methyl-1H-pyrimidine-2,4-dione
There total 8 articles about 1-((1S,3R,4S)-4-Benzyloxy-3-benzyloxymethyl-2-methylene-cyclopentyl)-5-methyl-1H-pyrimidine-2,4-dione which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: tetrahydrofuran / -78 - -65 °C
2: 1.) diisopinylcampheylborane (prepared from (+)-α-pinene), 2.) aq. NaOH, H2O2 / 1.) THF, -65 to -78 deg C
3: VO(acac)2, t-BuOOH / CH2Cl2
4: NaH, Bu4NI / dimethylformamide
5: 64 percent / LiH / dimethylformamide / 140 °C
6: DMSO, DCC, CH3PO3H2
7: Zn, TiCl4 / tetrahydrofuran; CH2Cl2
With
tert.-butylhydroperoxide; sodium hydroxide; bis(acetylacetonate)oxovanadium; (-)-diisopinocampheylborane; methylphosphonic acid; dihydrogen peroxide; titanium tetrachloride; tetra-(n-butyl)ammonium iodide; lithium hydride; sodium hydride; dimethyl sulfoxide; dicyclohexyl-carbodiimide; zinc;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(96)00594-X
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) diisopinylcampheylborane (prepared from (+)-α-pinene), 2.) aq. NaOH, H2O2 / 1.) THF, -65 to -78 deg C
2: VO(acac)2, t-BuOOH / CH2Cl2
3: NaH, Bu4NI / dimethylformamide
4: 64 percent / LiH / dimethylformamide / 140 °C
5: DMSO, DCC, CH3PO3H2
6: Zn, TiCl4 / tetrahydrofuran; CH2Cl2
With
tert.-butylhydroperoxide; sodium hydroxide; bis(acetylacetonate)oxovanadium; (-)-diisopinocampheylborane; methylphosphonic acid; dihydrogen peroxide; titanium tetrachloride; tetra-(n-butyl)ammonium iodide; lithium hydride; sodium hydride; dimethyl sulfoxide; dicyclohexyl-carbodiimide; zinc;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(96)00594-X
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 64 percent / LiH / dimethylformamide / 140 °C
2: DMSO, DCC, CH3PO3H2
3: Zn, TiCl4 / tetrahydrofuran; CH2Cl2
With
methylphosphonic acid; titanium tetrachloride; lithium hydride; dimethyl sulfoxide; dicyclohexyl-carbodiimide; zinc;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(96)00594-X
