2-Diazo-propionic acid (1R,2S,5R)-5-methyl-2-(1,1,3,3-tetramethyl-butyl)-cyclohexyl ester

Base Information

Chemical Name:2-Diazo-propionic acid (1R,2S,5R)-5-methyl-2-(1,1,3,3-tetramethyl-butyl)-cyclohexyl ester
CAS No.:188663-03-8
Molecular Formula:C₁₈H₃₂N₂O₂
Molecular Weight:308.464
Hs Code.:

Synonyms:

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Chemical Property of 2-Diazo-propionic acid (1R,2S,5R)-5-methyl-2-(1,1,3,3-tetramethyl-butyl)-cyclohexyl ester

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Technology Process of 2-Diazo-propionic acid (1R,2S,5R)-5-methyl-2-(1,1,3,3-tetramethyl-butyl)-cyclohexyl ester

There total 5 articles about 2-Diazo-propionic acid (1R,2S,5R)-5-methyl-2-(1,1,3,3-tetramethyl-butyl)-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 630-17-1
2,2-dimethylpropyl bromide

: 188663-03-8
2-Diazo-propionic acid (1R,2S,5R)-5-methyl-2-(1,1,3,3-tetramethyl-butyl)-cyclohexyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) Mg, 2.) CuI / 1.) Et₂O, reflux, 1 h, 2.) Et₂O, -20 deg C, 6 h; warm to room temperature, overnight; reflux, 4 h

2: 52 percent / Na / toluene; propan-2-ol / 20 h / Heating

3: 86 percent / NaOAc / acetonitrile / 2 h / Heating

4: 1.) NaH, 2.) NEt₃, MsN₃ / 1.) THF, 0 deg C, 30 min; room temperature, 12 h, 2.) CH₃CN, room temperature, 4 d

With copper(l) iodide; sodium acetate; sodium; sodium hydride; magnesium; triethylamine; Methanesulfonyl azide; In isopropyl alcohol; toluene; acetonitrile;
DOI:10.1016/S0040-4020(97)00002-1

Reference yield:

: 89-82-7,90449-51-7
pulegone

: 188663-03-8
2-Diazo-propionic acid (1R,2S,5R)-5-methyl-2-(1,1,3,3-tetramethyl-butyl)-cyclohexyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) Mg, 2.) CuI / 1.) Et₂O, reflux, 1 h, 2.) Et₂O, -20 deg C, 6 h; warm to room temperature, overnight; reflux, 4 h

2: 52 percent / Na / toluene; propan-2-ol / 20 h / Heating

3: 86 percent / NaOAc / acetonitrile / 2 h / Heating

4: 1.) NaH, 2.) NEt₃, MsN₃ / 1.) THF, 0 deg C, 30 min; room temperature, 12 h, 2.) CH₃CN, room temperature, 4 d

With copper(l) iodide; sodium acetate; sodium; sodium hydride; magnesium; triethylamine; Methanesulfonyl azide; In isopropyl alcohol; toluene; acetonitrile;
DOI:10.1016/S0040-4020(97)00002-1

Reference yield:

: 188662-98-8
(1R,2S,5R)-5-Methyl-2-(1,1,3,3-tetramethyl-butyl)-cyclohexanol

: 188663-03-8
2-Diazo-propionic acid (1R,2S,5R)-5-methyl-2-(1,1,3,3-tetramethyl-butyl)-cyclohexyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / NaOAc / acetonitrile / 2 h / Heating

2: 1.) NaH, 2.) NEt₃, MsN₃ / 1.) THF, 0 deg C, 30 min; room temperature, 12 h, 2.) CH₃CN, room temperature, 4 d

With sodium acetate; sodium hydride; triethylamine; Methanesulfonyl azide; In acetonitrile;
DOI:10.1016/S0040-4020(97)00002-1