1,4-Bis(4-chlorophenyl)piperazine

Base Information

• Chemical Name: 1,4-Bis(4-chlorophenyl)piperazine
• CAS No.: 3367-54-2
• Molecular Formula: C16H16 Cl2 N2
• Molecular Weight: 307.222
• NSC Number: 202934
• DSSTox Substance ID: DTXSID30308283
• Nikkaji Number: J1.499.551J
• Wikidata: Q82056075
• Mol file: 3367-54-2.mol

Synonyms:1,4-bis(4-chlorophenyl)piperazine;3367-54-2;NSC202934;DTXSID30308283;NSC-202934

Chemical Property of 1,4-Bis(4-chlorophenyl)piperazine

Chemical Property:

• Vapor Pressure: 6.33E-09mmHg at 25°C
• Boiling Point: 467.8°C at 760 mmHg
• Flash Point: 236.7°C
• Density: 1.275g/cm³
• XLogP3: 4.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 306.0690539
• Heavy Atom Count: 20
• Complexity: 259

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCN1C2=CC=C(C=C2)Cl)C3=CC=C(C=C3)Cl

Technology Process of 1,4-Bis(4-chlorophenyl)piperazine

There total 4 articles about 1,4-Bis(4-chlorophenyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

piperazine (110-85-0) + para-dichlorobenzene (106-46-7,84348-21-0) → 4-(4-chlorophenyl) piperazine (38212-33-8) + N,N'-di(p-chlorophenyl)piperazine (3367-54-2)

Guidance literature:

piperazine; With [2,2]bipyridinyl; nickel diacetate; sodium hydride; tert-Amyl alcohol; In tetrahydrofuran; at 65 ℃; for 2h;

para-dichlorobenzene; With styrene; In tetrahydrofuran; at 65 ℃; for 7h;

DOI:10.1016/S0040-4020(02)00750-0

Reference yield: 76.0%

piperazine (110-85-0) + bromochlorobenzene (106-39-8) → N,N'-di(p-chlorophenyl)piperazine (3367-54-2)

Guidance literature:

With potassium tert-butylate; [1,3-bis[(2,6-di-isopropylphenyl)-4,5-dihydroimidazol-2-ylidene]chloro][3-phenylallyl]palladium(II) catalyst; In 1,2-dimethoxyethane; at 80 ℃; for 15h; Inert atmosphere;

Reference yield:

sodium acetate (127-09-3) + 4-chloro-aniline (106-47-8) + ethylene dibromide (106-93-4) → N,N'-di(p-chlorophenyl)piperazine (3367-54-2)

Guidance literature:

at 140 ℃;

upstream raw materials:

sodium acetate

4-chloro-aniline

ethylene dibromide

piperazine

Downstream raw materials:

N,N'-bis-(4-chloro-2,6-dinitro-phenyl)-N,N'-dinitro-ethylenediamine

1-(4-aminophenyl)-4-(4-hydroxyphenyl)piperazine