C₁₆H₂₂N₂O₄Si

Base Information

• Chemical Name: C₁₆H₂₂N₂O₄Si
• CAS No.: 872355-75-4
• Molecular Formula: C₁₆H₂₂N₂O₄Si
• Molecular Weight: 334.447
• Mol file: 872355-75-4.mol

Synonyms:

Chemical Property of C₁₆H₂₂N₂O₄Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₆H₂₂N₂O₄Si

There total 7 articles about C₁₆H₂₂N₂O₄Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 3-methoxy-5-amino-6-trimethylsilylacetylenepyridine-2-carboxylate (872355-74-3) + acetyl chloride (75-36-5) → C16H22N2O4Si (872355-75-4)

Guidance literature:

With pyridine; In dichloromethane; at 0 - 20 ℃; for 1h;

Reference yield:

dihydroxypyridine (16867-04-2) → C16H22N2O4Si (872355-75-4)

Guidance literature:

Multi-step reaction with 7 steps

1.1: sodium hydroxide / water / 20 h / 5 - 20 °C

1.2: 0.5 h / 5 - 15 °C

2.1: phosphorus pentachloride; trichlorophosphate / 2.5 h / 100 °C / Heating / reflux

3.1: hydrogenchloride; tin(ll) chloride / water / 1.25 h / 5 - 80 °C

3.2: pH 8

4.1: triethylamine / palladium diacetate; 1,3-bis-(diphenylphosphino)propane / 18.17 h / 60 °C

5.1: sodium periodate; iodine / N,N-dimethyl-formamide / 18 h / 60 °C

6.1: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / dichloromethane / 4 h / 20 °C

7.1: pyridine / dichloromethane / 1 h / 0 - 20 °C

With pyridine; hydrogenchloride; sodium hydroxide; sodium periodate; copper(l) iodide; phosphorus pentachloride; iodine; triethylamine; tin(ll) chloride; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; palladium diacetate; 1,3-bis-(diphenylphosphino)propane; In dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

2-chloro-3-methoxy-5-nitropyridine (75711-00-1) → C16H22N2O4Si (872355-75-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: hydrogenchloride; tin(ll) chloride / water / 1.25 h / 5 - 80 °C

1.2: pH 8

2.1: triethylamine / palladium diacetate; 1,3-bis-(diphenylphosphino)propane / 18.17 h / 60 °C

3.1: sodium periodate; iodine / N,N-dimethyl-formamide / 18 h / 60 °C

4.1: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / dichloromethane / 4 h / 20 °C

5.1: pyridine / dichloromethane / 1 h / 0 - 20 °C

With pyridine; hydrogenchloride; sodium periodate; copper(l) iodide; iodine; triethylamine; tin(ll) chloride; bis-triphenylphosphine-palladium(II) chloride; palladium diacetate; 1,3-bis-(diphenylphosphino)propane; In dichloromethane; water; N,N-dimethyl-formamide;

upstream raw materials:

ethyl 3-methoxy-5-amino-6-trimethylsilylacetylenepyridine-2-carboxylate

acetyl chloride

dihydroxypyridine

2-chloro-3-methoxy-5-nitropyridine