4',5,7-tris(benzoyloxy)-8-(3-hydroxy-3-methylbutyl)isoflavone

Base Information

• Chemical Name: 4',5,7-tris(benzoyloxy)-8-(3-hydroxy-3-methylbutyl)isoflavone
• CAS No.: 210166-30-6
• Molecular Formula: C₄₁H₃₂O₉
• Molecular Weight: 668.7
• Mol file: 210166-30-6.mol

Synonyms:

Chemical Property of 4',5,7-tris(benzoyloxy)-8-(3-hydroxy-3-methylbutyl)isoflavone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4',5,7-tris(benzoyloxy)-8-(3-hydroxy-3-methylbutyl)isoflavone

There total 10 articles about 4',5,7-tris(benzoyloxy)-8-(3-hydroxy-3-methylbutyl)isoflavone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

benzoyl chloride (98-88-4) + lupiwighteone hydrate (104691-92-1) → 4',5,7-tris(benzoyloxy)-8-(3-hydroxy-3-methylbutyl)isoflavone (210166-30-6)

Guidance literature:

With potassium carbonate; In acetone; for 2.5h; Heating;

Reference yield:

1-[2,4-bis(benzyloxy)-6-hydroxyphenyl]ethanone (18065-05-9) → 4',5,7-tris(benzoyloxy)-8-(3-hydroxy-3-methylbutyl)isoflavone (210166-30-6)

Guidance literature:

Multi-step reaction with 10 steps

1: 76 percent / silver trifluoroacetate, I₂ / CHCl₃ / 0.5 h / Ambient temperature

2: 90 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 1.25 h / Ambient temperature

3: KOH / ethanol / 4.5 h / Heating

4: conc. aq. HCl / CHCl₃; ethanol / 1 h / 40 °C

5: 94 percent / pyridine / 2 h / 110 °C

6: 69 percent / thallium (III) nitrate trihydrate / CHCl₃ / 7 h / 40 °C

7: 79 percent / 10percent aq. NaOH / tetrahydrofuran / 3 h / Ambient temperature

8: 82 percent / Et₃N, PdCl₂, PPh₃, CuI / dimethylformamide / 2.5 h / 80 °C

9: 82 percent / H₂ / Raney Ni / tetrahydrofuran; methanol / 18 °C

10: 80 percent / K₂CO₃ / acetone / 2.5 h / Heating

With pyridine; hydrogenchloride; potassium hydroxide; sodium hydroxide; copper(l) iodide; hydrogen; iodine; silver trifluoroacetate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; thallium(III) nitrate; palladium dichloride; nickel; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide; acetone;

Reference yield:

3-Iod-2-hydroxy-4,6-dibenzyloxy-acetophenon (95165-66-5) → 4',5,7-tris(benzoyloxy)-8-(3-hydroxy-3-methylbutyl)isoflavone (210166-30-6)

Guidance literature:

Multi-step reaction with 9 steps

1: 90 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 1.25 h / Ambient temperature

2: KOH / ethanol / 4.5 h / Heating

3: conc. aq. HCl / CHCl₃; ethanol / 1 h / 40 °C

4: 94 percent / pyridine / 2 h / 110 °C

5: 69 percent / thallium (III) nitrate trihydrate / CHCl₃ / 7 h / 40 °C

6: 79 percent / 10percent aq. NaOH / tetrahydrofuran / 3 h / Ambient temperature

7: 82 percent / Et₃N, PdCl₂, PPh₃, CuI / dimethylformamide / 2.5 h / 80 °C

8: 82 percent / H₂ / Raney Ni / tetrahydrofuran; methanol / 18 °C

9: 80 percent / K₂CO₃ / acetone / 2.5 h / Heating

With pyridine; hydrogenchloride; potassium hydroxide; sodium hydroxide; copper(l) iodide; hydrogen; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; thallium(III) nitrate; palladium dichloride; nickel; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide; acetone;

upstream raw materials:

benzoyl chloride

lupiwighteone hydrate

1-[2,4-bis(benzyloxy)-6-hydroxyphenyl]ethanone

3-Iod-2-hydroxy-4,6-dibenzyloxy-acetophenon

Downstream raw materials:

4',7-bis(benzoyloxy)-5-acetoxy-8-(3-methyl-2-butenyl)isoflavone

atalantoflavone

lupiwighteone