4-methoxyphenyl (R)-2-phenylpropanoate

Base Information

• Chemical Name: 4-methoxyphenyl (R)-2-phenylpropanoate
• CAS No.: 1308679-17-5
• Molecular Formula: C₁₆H₁₆O₃
• Molecular Weight: 256.301
• Mol file: 1308679-17-5.mol

Synonyms:

Chemical Property of 4-methoxyphenyl (R)-2-phenylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-methoxyphenyl (R)-2-phenylpropanoate

There total 3 articles about 4-methoxyphenyl (R)-2-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-diazo-1-phenyl-2-propanone (3893-35-4) + 4-methoxy-phenol (150-76-5) → 4-methoxyphenyl (R)-2-phenylpropanoate (1308679-17-5) + (S)-4-methoxyphenyl 2-phenylpropanoate (141964-53-6)

Guidance literature:

With C₁₂H₁₄N₂S; In 2-methyltetrahydrofuran; at 40 ℃; for 16h; Overall yield = 72 percent; enantioselective reaction; Inert atmosphere; Schlenk technique; Irradiation;

DOI:10.1021/acs.orglett.9b03227

Reference yield:

2.2-dimethyl-5-phenyl-1,3-dioxane-4,6-dione (15231-78-4) → 4-methoxyphenyl (R)-2-phenylpropanoate (1308679-17-5) + (S)-4-methoxyphenyl 2-phenylpropanoate (141964-53-6)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere

2: cesium chloride; potassium phosphate; (R)-2,10-di-tert-butyl-3,9-dimethoxy-6-methyl-6-(1-naphthalen-1-ylethyl)-4,8-bis(3,4,5-trifluorophenyl)-6,7-dihydro-5H-dibenzo[c,e]-azepinium bromide / 48 h / 20 °C / Inert atmosphere

With potassium phosphate; (R)-2,10-di-tert-butyl-3,9-dimethoxy-6-methyl-6-(1-naphthalen-1-ylethyl)-4,8-bis(3,4,5-trifluorophenyl)-6,7-dihydro-5H-dibenzo[c,e]-azepinium bromide; cesium chloride; potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1002/ejoc.201800331

Reference yield:

2,2,5-trimethyl-5-phenyl-1,3-dioxane-4,6-dione (24131-01-9) + 4-methoxy-phenol (150-76-5) → 4-methoxyphenyl (R)-2-phenylpropanoate (1308679-17-5) + (S)-4-methoxyphenyl 2-phenylpropanoate (141964-53-6)

Guidance literature:

With potassium phosphate; (R)-2,10-di-tert-butyl-3,9-dimethoxy-6-methyl-6-(1-naphthalen-1-ylethyl)-4,8-bis(3,4,5-trifluorophenyl)-6,7-dihydro-5H-dibenzo[c,e]-azepinium bromide; cesium chloride; at 20 ℃; for 48h; Reagent/catalyst; Temperature; Overall yield = 79 %; Overall yield = 40.5 mg; enantioselective reaction; Catalytic behavior; Inert atmosphere;

DOI:10.1002/ejoc.201800331

upstream raw materials:

2,2,5-trimethyl-5-phenyl-1,3-dioxane-4,6-dione

4-methoxy-phenol

2.2-dimethyl-5-phenyl-1,3-dioxane-4,6-dione

1-diazo-1-phenyl-2-propanone