rac-4-{[(2S,3S,4S)-2-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-4-(2,2-dimethyl-propyl)-pyrrolidine-1-carbonyl]amino}-benzoic acid

Base Information

Chemical Name:rac-4-{[(2S,3S,4S)-2-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-4-(2,2-dimethyl-propyl)-pyrrolidine-1-carbonyl]amino}-benzoic acid
CAS No.:1289569-90-9
Molecular Formula:C₃₀H₂₇Cl₂F₂N₃O₃
Molecular Weight:586.465
Hs Code.:

rac-4-{[(2S,3S,4S)-2-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-4-(2,2-dimethyl-propyl)-pyrrolidine-1-carbonyl]amino}-benzoic acid

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Chemical Property of rac-4-{[(2S,3S,4S)-2-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-4-(2,2-dimethyl-propyl)-pyrrolidine-1-carbonyl]amino}-benzoic acid

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Technology Process of rac-4-{[(2S,3S,4S)-2-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-4-(2,2-dimethyl-propyl)-pyrrolidine-1-carbonyl]amino}-benzoic acid

There total 7 articles about rac-4-{[(2S,3S,4S)-2-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-4-(2,2-dimethyl-propyl)-pyrrolidine-1-carbonyl]amino}-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 85070-48-0
2-fluoro-3-chlorobenzaldehyde

: 1289569-90-9
rac-4-{[(2S,3S,4S)-2-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-4-(2,2-dimethyl-propyl)-pyrrolidine-1-carbonyl]amino}-benzoic acid

: 1289569-91-0
4-{[(2R,3R,4R)-2-(3-chloro-2-fluorophenyl)-3-(4-chloro-2-fluorophenyl)-3-cyano-4-(2,2-dimethylpropyl)pyrrolidine-1-carbonyl]amino}benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: dichloromethane; tetrahydrofuran / 20 °C

2: potassium hydroxide / dimethyl sulfoxide / 20 °C

3: dichloromethane / 1 h / 20 °C

4: lithium hydroxide; methanol / tetrahydrofuran / 2 h / 20 °C

5: SFC chiral column / Resolution of racemate

With methanol; lithium hydroxide; potassium hydroxide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 1289570-80-4
[1-(3-chloro-2-fluorophenyl)meth-(E)-ylidene]methylamine

: 1289569-90-9
rac-4-{[(2S,3S,4S)-2-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-4-(2,2-dimethyl-propyl)-pyrrolidine-1-carbonyl]amino}-benzoic acid

: 1289569-91-0
4-{[(2R,3R,4R)-2-(3-chloro-2-fluorophenyl)-3-(4-chloro-2-fluorophenyl)-3-cyano-4-(2,2-dimethylpropyl)pyrrolidine-1-carbonyl]amino}benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: potassium hydroxide / dimethyl sulfoxide / 20 °C

2: dichloromethane / 1 h / 20 °C

3: lithium hydroxide; methanol / tetrahydrofuran / 2 h / 20 °C

4: SFC chiral column / Resolution of racemate

With methanol; lithium hydroxide; potassium hydroxide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 75279-53-7
2-(4-chloro-2-fluoro-phenyl)acetonitrile

: 1289569-90-9
rac-4-{[(2S,3S,4S)-2-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-4-(2,2-dimethyl-propyl)-pyrrolidine-1-carbonyl]amino}-benzoic acid

: 1289569-91-0
4-{[(2R,3R,4R)-2-(3-chloro-2-fluorophenyl)-3-(4-chloro-2-fluorophenyl)-3-cyano-4-(2,2-dimethylpropyl)pyrrolidine-1-carbonyl]amino}benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydroxide / isopropyl alcohol / 20 °C

2: potassium hydroxide / dimethyl sulfoxide / 20 °C

3: dichloromethane / 1 h / 20 °C

4: lithium hydroxide; methanol / tetrahydrofuran / 2 h / 20 °C

5: SFC chiral column / Resolution of racemate

With methanol; sodium hydroxide; lithium hydroxide; potassium hydroxide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; isopropyl alcohol;