C₂₇H₂₅NO₄

Base Information

• Chemical Name: C₂₇H₂₅NO₄
• CAS No.: 1291080-80-2
• Molecular Formula: C₂₇H₂₅NO₄
• Molecular Weight: 427.5
• Mol file: 1291080-80-2.mol

Synonyms:

Chemical Property of C₂₇H₂₅NO₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₇H₂₅NO₄

There total 5 articles about C₂₇H₂₅NO₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,N-dibenzyl-2-bromoaniline (1075193-04-2) → C27H25NO4 (1291080-80-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.08 h / -78 °C

1.2: -78 °C

2.1: dichloromethane / 12 h / Reflux; Inert atmosphere

With n-butyllithium; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1021/acs.orglett.9b04224

Reference yield:

2-bromoaniline (615-36-1) → C27H25NO4 (1291080-80-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 120 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.08 h / -78 °C

2.2: -78 °C

3.1: dichloromethane / 12 h / Reflux; Inert atmosphere

With n-butyllithium; potassium carbonate; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/acs.orglett.9b04224

Reference yield:

benzyl bromide (100-39-0) → C27H25NO4 (1291080-80-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 120 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.08 h / -78 °C

2.2: -78 °C

3.1: dichloromethane / 12 h / Reflux; Inert atmosphere

With n-butyllithium; potassium carbonate; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/acs.orglett.9b04224

upstream raw materials:

C₂₇H₂₅NO₄

2-bromoaniline

N,N-dibenzyl-2-bromoaniline

benzyl bromide

Refernces

• 1、 Mori, Keiji,Ehara, Kensuke,Kurihara, Kazuki,Akiyama, Takahiko. "Selective activation of enantiotopic C(sp3)-hydrogen by means of chiral phosphoric acid: Asymmetric synthesis of tetrahydroquinoline derivatives". supporting information; scheme or table. p. 6166 - 6169. Retrieved 2011/06/21.