phenyl thiazolo[5,4-b]pyridin-2-ylcarbamate

Base Information

• Chemical Name: phenyl thiazolo[5,4-b]pyridin-2-ylcarbamate
• CAS No.: 50621-23-3
• Molecular Formula: C₁₃H₉N₃O₂S
• Molecular Weight: 271.299
• Mol file: 50621-23-3.mol

Synonyms:

Chemical Property of phenyl thiazolo[5,4-b]pyridin-2-ylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of phenyl thiazolo[5,4-b]pyridin-2-ylcarbamate

There total 3 articles about phenyl thiazolo[5,4-b]pyridin-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

bis(phenyl) carbonate (102-09-0) + 2-aminothiazolo<5,4-b>pyridine (31784-70-0) → phenyl thiazolo[5,4-b]pyridin-2-ylcarbamate (50621-23-3)

Guidance literature:

2-aminothiazolo<5,4-b>pyridine; With sodium hydride; In tetrahydrofuran;

bis(phenyl) carbonate; In tetrahydrofuran;

DOI:10.1080/10426507.2010.497518

Reference yield:

2-chloro-3-aminopyridine (6298-19-7) → phenyl thiazolo[5,4-b]pyridin-2-ylcarbamate (50621-23-3)

Guidance literature:

Multi-step reaction with 4 steps

1: acetone / 8 h / Reflux

2: sodium methylate / 1-methyl-pyrrolidin-2-one / 8 h / Reflux

3: sulfuric acid; water / Reflux

4: sodium hydride / tetrahydrofuran

With sulfuric acid; water; sodium methylate; sodium hydride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; acetone;

DOI:10.1080/10426507.2010.497518

Reference yield:

N-benzoyl-N'-(2-chloro-3-pyridyl)thiourea → phenyl thiazolo[5,4-b]pyridin-2-ylcarbamate (50621-23-3)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium methylate / 1-methyl-pyrrolidin-2-one / 8 h / Reflux

2: sulfuric acid; water / Reflux

3: sodium hydride / tetrahydrofuran

With sulfuric acid; water; sodium methylate; sodium hydride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one;

DOI:10.1080/10426507.2010.497518

upstream raw materials:

bis(phenyl) carbonate

2-aminothiazolo<5,4-b>pyridine

2-chloro-3-aminopyridine

Downstream raw materials:

C₁₄H₁₂N₄OS

C₁₃H₉ClN₄OS

C₁₃H₉N₅O₃S

C₁₄H₁₂N₄OS