Technology Process of ethyl 3-(5-acetamido-4-ethoxy-2-nitrophenyl)-2-cyano-3-oxopropanoate
There total 6 articles about ethyl 3-(5-acetamido-4-ethoxy-2-nitrophenyl)-2-cyano-3-oxopropanoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydroxide / methanol; water / 5 h / 20 °C / Large scale reaction
1.2: 20 °C / pH 2 - 3
2.1: nitric acid; acetic acid / 6 h / 25 - 35 °C / Large scale reaction
3.1: sulfuryl dichloride / dichloromethane / 1 h / 50 °C
4.1: sodium methylate / tetrahydrofuran / 1 h / 40 - 50 °C / Large scale reaction
4.2: 2 h / 0 °C
With
sulfuryl dichloride; nitric acid; sodium methylate; acetic acid; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.3987/COM-11-12343
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: acetic acid / 3 h / 60 °C / Large scale reaction
2.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 60 °C / Large scale reaction
3.1: sodium hydroxide / methanol; water / 5 h / 20 °C / Large scale reaction
3.2: 20 °C / pH 2 - 3
4.1: nitric acid; acetic acid / 6 h / 25 - 35 °C / Large scale reaction
5.1: sulfuryl dichloride / dichloromethane / 1 h / 50 °C
6.1: sodium methylate / tetrahydrofuran / 1 h / 40 - 50 °C / Large scale reaction
6.2: 2 h / 0 °C
With
sulfuryl dichloride; nitric acid; sodium methylate; potassium carbonate; acetic acid; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.3987/COM-11-12343
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: nitric acid; acetic acid / 6 h / 25 - 35 °C / Large scale reaction
2.1: sulfuryl dichloride / dichloromethane / 1 h / 50 °C
3.1: sodium methylate / tetrahydrofuran / 1 h / 40 - 50 °C / Large scale reaction
3.2: 2 h / 0 °C
With
sulfuryl dichloride; nitric acid; sodium methylate; acetic acid;
In
tetrahydrofuran; dichloromethane;
DOI:10.3987/COM-11-12343
