1-((R)-1-{(S)-1-Azidomethyl-2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethoxy}-ethyl)-5-methyl-1H-pyrimidine-2,4-dione

Base Information

• Chemical Name: 1-((R)-1-{(S)-1-Azidomethyl-2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethoxy}-ethyl)-5-methyl-1H-pyrimidine-2,4-dione
• CAS No.: 173961-38-1
• Molecular Formula: C₃₁H₃₃N₅O₆
• Molecular Weight: 571.633
• Mol file: 173961-38-1.mol

Synonyms:

Chemical Property of 1-((R)-1-{(S)-1-Azidomethyl-2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethoxy}-ethyl)-5-methyl-1H-pyrimidine-2,4-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-((R)-1-{(S)-1-Azidomethyl-2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethoxy}-ethyl)-5-methyl-1H-pyrimidine-2,4-dione

There total 4 articles about 1-((R)-1-{(S)-1-Azidomethyl-2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethoxy}-ethyl)-5-methyl-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Methanesulfonic acid (R)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propyl ester (173961-36-9) → 1-((R)-1-{(S)-1-Azidomethyl-2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethoxy}-ethyl)-5-methyl-1H-pyrimidine-2,4-dione (173961-38-1)

Guidance literature:

With sodium azide; In N,N-dimethyl-formamide; at 100 ℃;

DOI:10.1080/15257779508010708

Reference yield:

5'-O-benzoyl-2'-deoxy-3'-O-mesyl-2',3'-secothymidine (130515-58-1) → 1-((R)-1-{(S)-1-Azidomethyl-2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethoxy}-ethyl)-5-methyl-1H-pyrimidine-2,4-dione (173961-38-1)

Guidance literature:

Multi-step reaction with 3 steps

1: NH₄OH

2: pyridine

3: NaN₃ / dimethylformamide / 100 °C

With pyridine; ammonium hydroxide; sodium azide; In N,N-dimethyl-formamide;

DOI:10.1080/15257779508010708

Reference yield:

Methanesulfonic acid (R)-3-hydroxy-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propyl ester (173961-35-8) → 1-((R)-1-{(S)-1-Azidomethyl-2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethoxy}-ethyl)-5-methyl-1H-pyrimidine-2,4-dione (173961-38-1)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine

2: NaN₃ / dimethylformamide / 100 °C

With pyridine; sodium azide; In N,N-dimethyl-formamide;

DOI:10.1080/15257779508010708

upstream raw materials:

Methanesulfonic acid (R)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propyl ester

4,4'-dimethoxytrityl chloride

5'-O-benzoyl-2'-deoxy-3'-O-mesyl-2',3'-secothymidine

Methanesulfonic acid (R)-3-hydroxy-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propyl ester

Downstream raw materials:

{(S)-3-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propyl}-carbamic acid (S)-3-hydroxy-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propyl ester

Acetic acid (S)-3-{(S)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propylcarbamoyloxy}-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propyl ester