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Technology Process of N-[2-({2-[di(2H3)methylamino]ethyl}(methyl)amino)-4-(2H3)methoxy-5-({4-[1-(2H3)methyl(2,4,5,6,7-2H3)-1H-indol-3-yl](5-2H)pyrimidin-2-yl}amino)phenyl](2H3)prop-2-enamide

N-[2-({2-[di(2H3)methylamino]ethyl}(methyl)amino)-4-(2H3)methoxy-5-({4-[1-(2H3)methyl(2,4,5,6,7-2H3)-1H-indol-3-yl](5-2H)pyrimidin-2-yl}amino)phenyl](2H3)prop-2-enamide

Base Information
  • Chemical Name:N-[2-({2-[di(2H3)methylamino]ethyl}(methyl)amino)-4-(2H3)methoxy-5-({4-[1-(2H3)methyl(2,4,5,6,7-2H3)-1H-indol-3-yl](5-2H)pyrimidin-2-yl}amino)phenyl](2H3)prop-2-enamide
  • CAS No.:1638281-44-3
  • Molecular Formula:C28H33N7O2
  • Molecular Weight:520.449
  • Hs Code.:
N-[2-({2-[di(<sup>2</sup>H<sub>3</sub>)methylamino]ethyl}(methyl)amino)-4-(<sup>2</sup>H<sub>3</sub>)methoxy-5-({4-[1-(<sup>2</sup>H<sub>3</sub>)methyl(2,4,5,6,7-<sup>2</sup>H<sub>3</sub>)-1H-indol-3-yl](5-<sup>2</sup>H)pyrimidin-2-yl}amino)phenyl](<sup>2</sup>H<sub>3</sub>)prop-2-enamide

Synonyms:

Suppliers and Price of N-[2-({2-[di(2H3)methylamino]ethyl}(methyl)amino)-4-(2H3)methoxy-5-({4-[1-(2H3)methyl(2,4,5,6,7-2H3)-1H-indol-3-yl](5-2H)pyrimidin-2-yl}amino)phenyl](2H3)prop-2-enamide
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Chemical Property of N-[2-({2-[di(2H3)methylamino]ethyl}(methyl)amino)-4-(2H3)methoxy-5-({4-[1-(2H3)methyl(2,4,5,6,7-2H3)-1H-indol-3-yl](5-2H)pyrimidin-2-yl}amino)phenyl](2H3)prop-2-enamide
Chemical Property:
Purity/Quality:

97% *data from raw suppliers

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Technology Process of N-[2-({2-[di(2H3)methylamino]ethyl}(methyl)amino)-4-(2H3)methoxy-5-({4-[1-(2H3)methyl(2,4,5,6,7-2H3)-1H-indol-3-yl](5-2H)pyrimidin-2-yl}amino)phenyl](2H3)prop-2-enamide

There total 43 articles about N-[2-({2-[di(2H3)methylamino]ethyl}(methyl)amino)-4-(2H3)methoxy-5-({4-[1-(2H3)methyl(2,4,5,6,7-2H3)-1H-indol-3-yl](5-2H)pyrimidin-2-yl}amino)phenyl](2H3)prop-2-enamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

N<sub>1</sub>-{2-[bis(methyl-d3)amino]-diethyl}-5-(methyloxy-d3)-N<sub>1</sub>-methyl-N<sub>4</sub>-[4-(1-methyl-indol-3-yl)pyrimidin-2-yl]benzene-1,2,4-triamine

N1-{2-[bis(methyl-d3)amino]-diethyl}-5-(methyloxy-d3)-N1-methyl-N4-[4-(1-methyl-indol-3-yl)pyrimidin-2-yl]benzene-1,2,4-triamine

acryloyl chloride
814-68-6,25189-84-8

acryloyl chloride

N-(2-[2-bis(methyl-d3)aminoethyl(methyl)amino]-4-(methyloxy-d3)-5-{[4-(1-methyl-1H-indole-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide
1638281-44-3

N-(2-[2-bis(methyl-d3)aminoethyl(methyl)amino]-4-(methyloxy-d3)-5-{[4-(1-methyl-1H-indole-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide

Guidance literature:
With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 1.5h;

Reference yield: 94.0%

N<sub>1</sub>-{2-[bis(methyl-d3)amino]-1,1-dideutinoethyl}-5-methoxy-N<sub>1</sub>-methyl-N<sub>4</sub>-[4-(1-methyl-indol-3-yl)pyrimidin-2-yl]benzene-1,2,4-triamine

N1-{2-[bis(methyl-d3)amino]-1,1-dideutinoethyl}-5-methoxy-N1-methyl-N4-[4-(1-methyl-indol-3-yl)pyrimidin-2-yl]benzene-1,2,4-triamine

2-chloropropionyl chloride
625-36-5

2-chloropropionyl chloride

N-(2-[2-bis(methyl-d3)amino-1,1-dideutinoethyl(methyl)amino]-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidine-2-yl]amino}phenyl)prop-2-enamide
1638281-44-3

N-(2-[2-bis(methyl-d3)amino-1,1-dideutinoethyl(methyl)amino]-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidine-2-yl]amino}phenyl)prop-2-enamide

Guidance literature:
N1-{2-[bis(methyl-d3)amino]-1,1-dideutinoethyl}-5-methoxy-N1-methyl-N4-[4-(1-methyl-indol-3-yl)pyrimidin-2-yl]benzene-1,2,4-triamine; 2-chloropropionyl chloride; With water; In tetrahydrofuran; at 20 ℃; for 0.25h;
With sodium hydroxide; In tetrahydrofuran; methanol; at 20 - 65 ℃;

Reference yield: 90.0%

N<sub>1</sub>-{2-[bis(methyl-d3)amino]-diethyl}-5-methoxy-N<sub>1</sub>-methyl-N<sub>4</sub>-[4-(1-(methyl-d3)-indol-3-yl)pyrimidin-2-yl]benzene-1,2,4-triamine

N1-{2-[bis(methyl-d3)amino]-diethyl}-5-methoxy-N1-methyl-N4-[4-(1-(methyl-d3)-indol-3-yl)pyrimidin-2-yl]benzene-1,2,4-triamine

acryloyl chloride
814-68-6,25189-84-8

acryloyl chloride

N-(2-{2-di(D<sub>3</sub>-methyl)aminoethyl-methylamino}-4-methoxy-5-{[4-(1-(D<sub>3</sub>-methyl)indol-3-yl)pyrimidin-2-yl]amino}phenyl)-2-acrylamide
1638281-44-3

N-(2-{2-di(D3-methyl)aminoethyl-methylamino}-4-methoxy-5-{[4-(1-(D3-methyl)indol-3-yl)pyrimidin-2-yl]amino}phenyl)-2-acrylamide

Guidance literature:
With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 1.5h;
upstream raw materials:

indole

acryloyl chloride

4-fluoro-2-methoxyaniline

4-fluoro-2-methoxy-5-nitro-phenylamine

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