2-N-(4,4’-dimethoxytrityl)-gunaosine

Base Information

• Chemical Name: 2-N-(4,4’-dimethoxytrityl)-gunaosine
• CAS No.: 132470-74-7
• Molecular Formula: C₃₁H₃₁N₅O₇
• Molecular Weight: 585.616
• Mol file: 132470-74-7.mol

Synonyms:

Chemical Property of 2-N-(4,4’-dimethoxytrityl)-gunaosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-N-(4,4’-dimethoxytrityl)-gunaosine

There total 1 articles about 2-N-(4,4’-dimethoxytrityl)-gunaosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

4,4'-dimethoxytrityl chloride (40615-36-9) + N2,O5'-bis(triphenylmethyl)guanosine (104532-06-1) → 2-N-(4,4’-dimethoxytrityl)-gunaosine (132470-74-7) + 2-N,5’-O-bis(4,4’-dimethoxytrityl)-gunaosine (132625-21-9)

Guidance literature:

N²,O^5'-bis(triphenylmethyl)guanosine; With pyridine; chloro-trimethyl-silane; In N,N-dimethyl-formamide; for 1h; Inert atmosphere;

4,4'-dimethoxytrityl chloride; In N,N-dimethyl-formamide; Inert atmosphere;

DOI:10.1039/c7ob02296d

Reference yield: 81.0%

2-N-(4,4’-dimethoxytrityl)-gunaosine (132470-74-7) + trimethyl orthoformate (149-73-5) → 2-N-(4,4'-dimethoxytrityl)-2',3'-di-O-methoxymethyleneguanosine (98151-72-5) + 2-{[Bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-9-((3aR,4R,6R,6aR)-2-methoxy-6-methoxymethoxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-1,9-dihydro-purin-6-one

Guidance literature:

With chloro-trimethyl-silane; In N,N-dimethyl-formamide; for 5h;

Reference yield:

2-N-(4,4’-dimethoxytrityl)-gunaosine (132470-74-7) → C48H58N5O15P (132470-69-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 81 percent / trimethylsilyl chloride / dimethylformamide / 5 h

2: dioxane / Ambient temperature

3: 1. pyridine 2. 1-methylimidazole / 2. r.t.

With pyridine; 1-methyl-1H-imidazole; chloro-trimethyl-silane; In 1,4-dioxane; N,N-dimethyl-formamide;

upstream raw materials:

4,4'-dimethoxytrityl chloride

N²,O^5'-bis(triphenylmethyl)guanosine

Downstream raw materials:

2-N-(4,4'-dimethoxytrityl)-2',3'-di-O-methoxymethyleneguanosine

Diisopropyl-phosphoramidous acid (3aR,4R,6R,6aR)-6-(2-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-6-oxo-1,6-dihydro-purin-9-yl)-2-methoxy-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester hexadecyl ester

C₄₈H₅₈N₅O₁₅P

C₅₉H₈₀N₅O₁₅P