RO6885247)

Base Information

• Chemical Name: RO6885247)
• CAS No.: 1449598-06-4
• Molecular Formula: C₂₄H₂₈N₆O
• Molecular Weight: 416.526
• Mol file: 1449598-06-4.mol

Synonyms:

Chemical Property of RO6885247)

Chemical Property:

• PKA: 9.13±0.10(Predicted)
• Density: 1.31±0.1 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

RG7800 >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of RO6885247)

There total 14 articles about RO6885247) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.4%

(E)-1-(4-ethyl-6-methylpyrazolo[1,5-a]pyrazin-2-yl)-N-[3-methyl-5-(1-methyl-4-piperidyl)-2-pyridyl]methanimine + chloroacetyl chloride (79-04-9) → RG7800 (1449598-06-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; zinc(II) chloride; In dichloromethane; at 0 - 20 ℃; for 4h; Time;

Reference yield: 69.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-(4-ethyl-6-methylpyrazolo[1,5-a]pyrazin-2-yl)-9-methyl-7-(piperidin-4-yl)-4H-pyrido[1,2-a]pyrimidin-4-one → RG7800 (1449598-06-4)

Guidance literature:

With sodium tris(acetoxy)borohydride; In dichloromethane; water; at 5 - 10 ℃; for 0.666667h;

DOI:10.1021/acs.jmedchem.6b00459

Reference yield: 61.5%

Methoxyacetyl chloride (38870-89-2) + (E)-1-(4-ethyl-6-methylpyrazolo[1,5-a]pyrazin-2-yl)-N-[3-methyl-5-(1-methyl-4-piperidyl)-2-pyridyl]methanimine → RG7800 (1449598-06-4)

Guidance literature:

With triethylamine; In toluene; at -10 - 85 ℃; for 8h;

upstream raw materials:

ethyl 4-hydroxy-6-methylpyrazolo[1,5-a]pyrazine-2-carboxylate

formaldehyd

diethyl 1H-pyrazole-3,5-dicarboxylate

Methoxyacetyl chloride