ethyl 2-(trifluoromethyl)isonicotinate

Base Information

• Chemical Name: ethyl 2-(trifluoromethyl)isonicotinate
• CAS No.: 1214351-44-6
• Molecular Formula: C₉H₈F₃NO₂
• Molecular Weight: 219.163
• Mol file: 1214351-44-6.mol

Synonyms:

Chemical Property of ethyl 2-(trifluoromethyl)isonicotinate

Chemical Property:

• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Ethyl2-(trifluoromethyl)isonicotinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 2-(trifluoromethyl)isonicotinate

There total 4 articles about ethyl 2-(trifluoromethyl)isonicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethanol (64-17-5) + carbon monoxide (201230-82-2) + 4-chloro-2-trifluoromethylpyridine (131748-14-6) → 2-trifluoromethyl-isonicotinic acid ethyl ester (1214351-44-6)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; triethylamine; at 130 ℃; for 18h; under 52505.3 Torr;

Reference yield:

ethanol (64-17-5) + 2-(trifluoromethyl)-4-pyridinecarboxylic acid (131747-41-6) → 2-trifluoromethyl-isonicotinic acid ethyl ester (1214351-44-6)

Guidance literature:

2-(trifluoromethyl)-4-pyridinecarboxylic acid; With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃; for 3h;

ethanol; With triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/acs.orglett.6b01612

Reference yield:

isonicotinic acid ethylester (1570-45-2) + bis(((trifluoromethyl)sulfinyl)oxy)zinc (39971-65-8) → 2-trifluoromethyl-isonicotinic acid ethyl ester (1214351-44-6) + C9H8F3NO2 (1214337-41-3)

Guidance literature:

With tert.-butylhydroperoxide; In dichloromethane; water; at 25 ℃; Overall yield = 35 %;

DOI:10.1038/nature11680

upstream raw materials:

isonicotinic acid ethylester

bis(((trifluoromethyl)sulfinyl)oxy)zinc

ethanol

carbon monoxide