methanesulfonic acid 2-[2-(2-2-[6-(4-chloro-but-2-enoylamino)-4-(4,5-dichloro-2-fluoro-phenylamino)-quinazolin-7-yloxy]-ethoxy-ethoxy)-ethoxy]-ethyl ester

Base Information

• Chemical Name: methanesulfonic acid 2-[2-(2-2-[6-(4-chloro-but-2-enoylamino)-4-(4,5-dichloro-2-fluoro-phenylamino)-quinazolin-7-yloxy]-ethoxy-ethoxy)-ethoxy]-ethyl ester
• CAS No.: 1186029-50-4
• Molecular Formula: C₂₇H₃₀Cl₃FN₄O₈S
• Molecular Weight: 695.981

Synonyms:

Chemical Property of methanesulfonic acid 2-[2-(2-2-[6-(4-chloro-but-2-enoylamino)-4-(4,5-dichloro-2-fluoro-phenylamino)-quinazolin-7-yloxy]-ethoxy-ethoxy)-ethoxy]-ethyl ester

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Technology Process of methanesulfonic acid 2-[2-(2-2-[6-(4-chloro-but-2-enoylamino)-4-(4,5-dichloro-2-fluoro-phenylamino)-quinazolin-7-yloxy]-ethoxy-ethoxy)-ethoxy]-ethyl ester

There total 1 articles about methanesulfonic acid 2-[2-(2-2-[6-(4-chloro-but-2-enoylamino)-4-(4,5-dichloro-2-fluoro-phenylamino)-quinazolin-7-yloxy]-ethoxy-ethoxy)-ethoxy]-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chloro-but-2-enoic acid[4-(4,5-dichloro-2-fluoro-phenylamino)-7-(2-2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy-ethoxy)-quinazolin-6-yl]-amide (1009828-66-3) + 4-bromo-but-2-enoic acid[4-(4,5-dichloro-2-fluoro-phenylamino)-7-(2-2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy-ethoxy)-quinazolin-6-yl]-amide (1009828-65-2) + methanesulfonyl chloride (124-63-0) → methanesulfonic acid 2-[2-(2-2-[6-(4-bromo-but-2-enoylamino)-4-(4,5-dichloro-2-fluoro-phenylamino)-quinazolin-7-yloxy]-ethoxy-ethoxy)-ethoxy]-ethyl ester (1186029-57-1) + methanesulfonic acid 2-[2-(2-2-[6-(4-chloro-but-2-enoylamino)-4-(4,5-dichloro-2-fluoro-phenylamino)-quinazolin-7-yloxy]-ethoxy-ethoxy)-ethoxy]-ethyl ester (1186029-50-4)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 1.5h;

DOI:10.1002/jlcr.1569

Reference yield:

methanesulfonic acid 2-[2-(2-2-[6-(4-bromo-but-2-enoylamino)-4-(4,5-dichloro-2-fluoro-phenylamino)-quinazolin-7-yloxy]-ethoxy-ethoxy)-ethoxy]-ethyl ester (1186029-57-1) + methanesulfonic acid 2-[2-(2-2-[6-(4-chloro-but-2-enoylamino)-4-(4,5-dichloro-2-fluoro-phenylamino)-quinazolin-7-yloxy]-ethoxy-ethoxy)-ethoxy]-ethyl ester (1186029-50-4) + 2,2'-iminobis[ethanol] (111-42-2) → methanesulfonic acid 2-[2-(2-2-[6-4-[bis-(2-hydroxy-ethyl)-amino]-but-2-enoylamino-4-(4,5-dichloro-2-fluoro-phenylamino)-quinazolin-7-yloxy]-ethoxy-ethoxy)-ethoxy]-ethyl ester (1186029-51-5)

Guidance literature:

With N,N-dimethyl-formamide; In tetrahydrofuran; at 0 ℃; for 1h;

DOI:10.1002/jlcr.1569

upstream raw materials:

4-chloro-but-2-enoic acid[4-(4,5-dichloro-2-fluoro-phenylamino)-7-(2-2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy-ethoxy)-quinazolin-6-yl]-amide

4-bromo-but-2-enoic acid[4-(4,5-dichloro-2-fluoro-phenylamino)-7-(2-2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy-ethoxy)-quinazolin-6-yl]-amide

methanesulfonyl chloride

Downstream raw materials:

methanesulfonic acid 2-[2-(2-2-[6-4-[bis-(2-hydroxy-ethyl)-amino]-but-2-enoylamino-4-(4,5-dichloro-2-fluoro-phenylamino)-quinazolin-7-yloxy]-ethoxy-ethoxy)-ethoxy]-ethyl ester

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