4-chloro-but-2-enoic acid[4-(4,5-dichloro-2-fluoro-phenylamino)-7-(2-2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy-ethoxy)-quinazolin-6-yl]-amide

Base Information

Chemical Name:4-chloro-but-2-enoic acid[4-(4,5-dichloro-2-fluoro-phenylamino)-7-(2-2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy-ethoxy)-quinazolin-6-yl]-amide
CAS No.:1009828-66-3
Molecular Formula:C₂₆H₂₈Cl₃FN₄O₆
Molecular Weight:617.889
Hs Code.:

4-chloro-but-2-enoic acid[4-(4,5-dichloro-2-fluoro-phenylamino)-7-(2-2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy-ethoxy)-quinazolin-6-yl]-amide

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Chemical Property of 4-chloro-but-2-enoic acid[4-(4,5-dichloro-2-fluoro-phenylamino)-7-(2-2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy-ethoxy)-quinazolin-6-yl]-amide

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Technology Process of 4-chloro-but-2-enoic acid[4-(4,5-dichloro-2-fluoro-phenylamino)-7-(2-2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy-ethoxy)-quinazolin-6-yl]-amide

There total 1 articles about 4-chloro-but-2-enoic acid[4-(4,5-dichloro-2-fluoro-phenylamino)-7-(2-2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy-ethoxy)-quinazolin-6-yl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24806-06-2
4-chloro-but-2-enoyl chloride

: 51544-74-2
4-bromocrotonic acid chloride

: 1186029-44-6
2-[2-(2-2-[6-amino-4-(4,5-dichloro-2-fluoro-phenylamino)-quinazolin-7-yloxy]-ethoxy-ethoxy)-ethoxy]-ethanol

: 1009828-66-3
4-chloro-but-2-enoic acid[4-(4,5-dichloro-2-fluoro-phenylamino)-7-(2-2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy-ethoxy)-quinazolin-6-yl]-amide

: 1009828-65-2
4-bromo-but-2-enoic acid[4-(4,5-dichloro-2-fluoro-phenylamino)-7-(2-2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy-ethoxy)-quinazolin-6-yl]-amide

Guidance literature:: In tetrahydrofuran; at 0 ℃;
DOI:10.1002/jlcr.1569

Reference yield:

: 1009828-66-3
4-chloro-but-2-enoic acid[4-(4,5-dichloro-2-fluoro-phenylamino)-7-(2-2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy-ethoxy)-quinazolin-6-yl]-amide

: 1009828-65-2
4-bromo-but-2-enoic acid[4-(4,5-dichloro-2-fluoro-phenylamino)-7-(2-2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy-ethoxy)-quinazolin-6-yl]-amide

: 124-40-3
dimethyl amine

: 1009828-68-5
4-dimethylamino-but-2-enoic acid[4-(4,5-dichloro-2-fluoro-phenylamino)-7-(2-2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy-ethoxy)-quinazolin-6-yl]-amide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 - 60 ℃; for 1h;
DOI:10.1002/jlcr.1569

Reference yield:

: 1009828-66-3
4-chloro-but-2-enoic acid[4-(4,5-dichloro-2-fluoro-phenylamino)-7-(2-2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy-ethoxy)-quinazolin-6-yl]-amide

: 1009828-65-2
4-bromo-but-2-enoic acid[4-(4,5-dichloro-2-fluoro-phenylamino)-7-(2-2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy-ethoxy)-quinazolin-6-yl]-amide

: 74-89-5
methylamine

: 1186029-45-7
4-methylamino-but-2-enoic acid[4-(4,5-dichloro-2-fluoro-phenylamino)-7-(2-2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy-ethoxy)-quinazolin-6-yl]-amide

Guidance literature:: 4-chloro-but-2-enoic acid[4-(4,5-dichloro-2-fluoro-phenylamino)-7-(2-2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy-ethoxy)-quinazolin-6-yl]-amide; 4-bromo-but-2-enoic acid[4-(4,5-dichloro-2-fluoro-phenylamino)-7-(2-2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy-ethoxy)-quinazolin-6-yl]-amide; methylamine; In dimethyl sulfoxide; at 0 ℃; for 0.25h;

With sodium hydroxide; In dimethyl sulfoxide; at 15 ℃; for 0.05h;
DOI:10.1002/jlcr.1569