(5S,7S,8S)-8-(bromomethyl)-5,6,7,8-tetrahydro-6,6-dimethyl-2-phenyl-5,7-methanoquinoline

Base Information

Chemical Name:(5S,7S,8S)-8-(bromomethyl)-5,6,7,8-tetrahydro-6,6-dimethyl-2-phenyl-5,7-methanoquinoline
CAS No.:1007589-01-6
Molecular Formula:C₁₉H₂₀BrN
Molecular Weight:342.279
Hs Code.:

Synonyms:

Suppliers and Price of (5S,7S,8S)-8-(bromomethyl)-5,6,7,8-tetrahydro-6,6-dimethyl-2-phenyl-5,7-methanoquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (5S,7S,8S)-8-(bromomethyl)-5,6,7,8-tetrahydro-6,6-dimethyl-2-phenyl-5,7-methanoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (5S,7S,8S)-8-(bromomethyl)-5,6,7,8-tetrahydro-6,6-dimethyl-2-phenyl-5,7-methanoquinoline

There total 1 articles about (5S,7S,8S)-8-(bromomethyl)-5,6,7,8-tetrahydro-6,6-dimethyl-2-phenyl-5,7-methanoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 211874-89-4
(5S,7S,8S)-8-hydroxymethyl-5,6,7,8-tetrahydro-6,6-dimethyl-2-phenyl-5,7-methanoquinoline

: 1007589-01-6
(5S,7S,8S)-8-(bromomethyl)-5,6,7,8-tetrahydro-6,6-dimethyl-2-phenyl-5,7-methanoquinoline

Guidance literature:: With dibromo sulfoxide; at 110 ℃; for 1.5h;
DOI:10.1039/b713257n

Reference yield: 20.0%

: 12112-67-3
bis(1,5-cyclooctadiene)diiridium(I) dichloride

: 1007589-01-6
(5S,7S,8S)-8-(bromomethyl)-5,6,7,8-tetrahydro-6,6-dimethyl-2-phenyl-5,7-methanoquinoline

: 1079-66-9,74391-44-9
chloro-diphenylphosphine

: 79060-88-1
sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate

: Ir(P(C₆H₅)2CH₂C₁₀H₇N(CH₃)2C₆H₅)(C₈H₁₂)⁽¹⁺⁾*B(C₆H₃(CF₃)2)4^(1-)=(Ir(P(C₆H₅)2CH₂C₁₀H₇N(CH₃)2C₆H₅)(C₈H₁₂))B(C₆H₃(CF₃)2)4

Guidance literature:: With magnesium; In dichloromethane; Mg heated under vac. (1 h); cooled; THF added; bromide in THF added; heated (70°C, 1 h); cooled; ClPPh2 added; stirred (room temp., 6 h);solvent removed; filtered (silica, toluene); dissolved in CH2Cl2; Ir co mplex added; refluxed (50 min); cooled; H2O and NaB(C6H3(CF3)2)4 added; stirred at room temp.; org. phase dried (MgSO4); evapd.; purified by flash chromy. (silica gel, pentane-CH2Cl2 2:3);
DOI:10.1039/b713257n

Reference yield:

: 1007589-01-6
(5S,7S,8S)-8-(bromomethyl)-5,6,7,8-tetrahydro-6,6-dimethyl-2-phenyl-5,7-methanoquinoline

: 829-85-6
diphenylphosphane

: (5S,7S,8S)-8-diphenylphosphinomethyl-5,6,7,8-tetrahydro-6,6-dimethyl-2-phenyl-5,7-methanoquinoline

Guidance literature:: (5S,7S,8S)-8-(bromomethyl)-5,6,7,8-tetrahydro-6,6-dimethyl-2-phenyl-5,7-methanoquinoline; With magnesium; In tetrahydrofuran; at 70 ℃; for 1h;

diphenylphosphane; In tetrahydrofuran; at 20 ℃; for 6h; Further stages.;
DOI:10.1039/b713257n