4-Chloro-1,2-dimethoxybenzene

Base Information

• Chemical Name: 4-Chloro-1,2-dimethoxybenzene
• CAS No.: 16766-27-1
• Molecular Formula: C8H9 Cl O2
• Molecular Weight: 172.611
• Hs Code.: 2909309090
• European Community (EC) Number: 846-801-6
• DSSTox Substance ID: DTXSID10168342
• Nikkaji Number: J323.688I
• Wikidata: Q83037926
• Mol file: 16766-27-1.mol

Synonyms:4-Chloro-1,2-dimethoxybenzene;16766-27-1;4-CHLOROVERATROLE;4-Chloro-1,2-dimethoxy-Benzene;Benzene, 4-chloro-1,2-dimethoxy-;1,2-Dimethoxy-4-chloro-benzene;1,2-dimethoxy-4-chlorobenzene;3,4-Dimethoxychlorobenzene;3,4-dimethoxy chlorobenzene;-Chloro-1,2-dimethoxybenzene;SCHEMBL2127233;DTXSID10168342;Benzene, 4-chloro-1,2-dimethoxy;AMY28221;MFCD01741851;AKOS015917179;4-Chloro-2-methoxyphenol, methyl ether;CS-0061908;FT-0686813;EN300-39343;A18287;W17044;1X-0320;J-010383;Z361900384

Chemical Property of 4-Chloro-1,2-dimethoxybenzene

Chemical Property:

• Vapor Pressure: 0.185mmHg at 25°C
• Melting Point: 75 °C
• Boiling Point: 218.5°Cat760mmHg
• Flash Point: 77.7°C
• PSA: 18.46000
• Density: 1.155g/cm³
• LogP: 2.35720
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 172.0291072
• Heavy Atom Count: 11
• Complexity: 119

Purity/Quality:

97% ^*data from raw suppliers

4-Chloro-1,2-dimethoxybenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C(C=C1)Cl)OC

Technology Process of 4-Chloro-1,2-dimethoxybenzene

There total 14 articles about 4-Chloro-1,2-dimethoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-Chloroguaiacol (16766-30-6) + methyl iodide (74-88-4) → 4-chloro-1,2-dimethoxybenzene (16766-27-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield: 98.0%

4-chloro-1,2-benzenediol (2138-22-9) + methyl iodide (74-88-4) → 4-chloro-1,2-dimethoxybenzene (16766-27-1)

Guidance literature:

With potassium carbonate; In acetone; for 16h; Reflux;

DOI:10.1021/jo402492d

Reference yield: 94.0%

1,2-dimethoxybenzene (91-16-7) → 4-chloro-1,2-dimethoxybenzene (16766-27-1)

Guidance literature:

With sulfuric acid; dicyclohexyl-chloroamine; at -10 - 0 ℃; for 1.5h;

upstream raw materials:

1,2-dimethoxybenzene

4-chloro-1,2-benzenediol

4,5-Dichlor-brenzcatechindimethylether

methyl iodide

Downstream raw materials:

5,6-dimethoxy-2-amino-3-carbethoxyindole

ethyl 2-cyano-2-(4,5-dimethoxy-2-nitro-phenyl)-acetate

3,4-dimethoxy-1,1'-biphenyl

3,4-dimethoxyaniline