1-(5-chloropyridin-2-yl)-1,4-diazepane

Base Information

• Chemical Name: 1-(5-chloropyridin-2-yl)-1,4-diazepane
• CAS No.: 502133-62-2
• Molecular Formula: C₁₀H₁₄ClN₃
• Molecular Weight: 211.694
• Hs Code.: 2933399990
• Mol file: 502133-62-2.mol

Synonyms:

Chemical Property of 1-(5-chloropyridin-2-yl)-1,4-diazepane

Chemical Property:

Purity/Quality:

99%min. ^*data from raw suppliers

1-(5-Chloropyridin-2-yl)-1,4-diazepane ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

Useful:

Technology Process of 1-(5-chloropyridin-2-yl)-1,4-diazepane

There total 4 articles about 1-(5-chloropyridin-2-yl)-1,4-diazepane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

tert-butyl 4-(5-chloropyridin-2-yl)-1,4-diazepane-1-carboxylate → 1-(5-chloropyridin-2-yl)-1,4-diazepane (502133-62-2)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; water; at 20 ℃; for 2h;

Reference yield: 65.0%

1,4-Diazacycloheptane (505-66-8) + 2,5 dichloropyridine (16110-09-1) → 1-(5-chloropyridin-2-yl)-1,4-diazepane (502133-62-2)

Guidance literature:

In 1,2-dimethoxyethane; at 150 ℃; for 12h;

DOI:10.1016/j.bmc.2019.01.035

Reference yield:

2-fluoro-5-chloropyridine (1480-65-5) → 1-(5-chloropyridin-2-yl)-1,4-diazepane (502133-62-2)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 90 °C / Sealed tube

2: hydrogenchloride / water; 1,4-dioxane / 2 h / 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; water;

upstream raw materials:

1,4-Diazacycloheptane

2,5 dichloropyridine

2-fluoro-5-chloropyridine

tert-butyl 1,4-diazepine-1-carboxylate

Refernces

• 1、 -. "INHIBITORS OF DIHYDROCERAMIDE DESATURASE FOR TREATING DISEASE". Paragraph 0145. . Retrieved 2019/08/20.