9-[5-O-(monomethoxytrityl)-3-deoxy-3-thio-3-S-(O,O-dimethylphosphorothiolate)-2-O-(isopropydimethylsilyl)-β-D-ribofuranosyl]hypoxanthine

Base Information

• Chemical Name: 9-[5-O-(monomethoxytrityl)-3-deoxy-3-thio-3-S-(O,O-dimethylphosphorothiolate)-2-O-(isopropydimethylsilyl)-β-D-ribofuranosyl]hypoxanthine
• CAS No.: 272785-87-2
• Molecular Formula: C₃₇H₄₅N₄O₈PSSi
• Molecular Weight: 764.912
• Mol file: 272785-87-2.mol

Synonyms:

Chemical Property of 9-[5-O-(monomethoxytrityl)-3-deoxy-3-thio-3-S-(O,O-dimethylphosphorothiolate)-2-O-(isopropydimethylsilyl)-β-D-ribofuranosyl]hypoxanthine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9-[5-O-(monomethoxytrityl)-3-deoxy-3-thio-3-S-(O,O-dimethylphosphorothiolate)-2-O-(isopropydimethylsilyl)-β-D-ribofuranosyl]hypoxanthine

There total 3 articles about 9-[5-O-(monomethoxytrityl)-3-deoxy-3-thio-3-S-(O,O-dimethylphosphorothiolate)-2-O-(isopropydimethylsilyl)-β-D-ribofuranosyl]hypoxanthine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

isopropyldimethylsilyl chloride (3634-56-8) → 9-[5-O-(monomethoxytrityl)-3-deoxy-3-thio-3-S-(O,O-dimethylphosphorothiolate)-2-O-(isopropydimethylsilyl)-β-D-ribofuranosyl]hypoxanthine (272785-87-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / pyridine

2: CH₂Cl₂

With pyridine; In dichloromethane; 1: silylation / 2: phosphitylation;

DOI:10.1080/15257770008035028

Reference yield:

9-[(2R,3S,4S,5R)-3-Hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-4-(5-nitro-pyridin-2-yldisulfanyl)-tetrahydro-furan-2-yl]-1,9-dihydro-purin-6-one (174467-01-7) → 9-[5-O-(monomethoxytrityl)-3-deoxy-3-thio-3-S-(O,O-dimethylphosphorothiolate)-2-O-(isopropydimethylsilyl)-β-D-ribofuranosyl]hypoxanthine (272785-87-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / pyridine

2: CH₂Cl₂

With pyridine; In dichloromethane; 1: silylation / 2: phosphitylation;

DOI:10.1080/15257770008035028

Reference yield:

9-[5-O-(monomethoxytrityl)-3-deoxy-3-thio-3-S-(5-nitropyridyl-2-disulfanyl)-2-O-(isopropydimethylsilyl)-β-D-ribofuranosyl]hypoxanthine (272785-86-1) + phosphorous acid trimethyl ester (121-45-9) → 9-[5-O-(monomethoxytrityl)-3-deoxy-3-thio-3-S-(O,O-dimethylphosphorothiolate)-2-O-(isopropydimethylsilyl)-β-D-ribofuranosyl]hypoxanthine (272785-87-2)

Guidance literature:

In dichloromethane;

DOI:10.1080/15257770008035028

upstream raw materials:

9-[5-O-(monomethoxytrityl)-3-deoxy-3-thio-3-S-(5-nitropyridyl-2-disulfanyl)-2-O-(isopropydimethylsilyl)-β-D-ribofuranosyl]hypoxanthine

phosphorous acid trimethyl ester

isopropyldimethylsilyl chloride

9-[(2R,3S,4S,5R)-3-Hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-4-(5-nitro-pyridin-2-yldisulfanyl)-tetrahydro-furan-2-yl]-1,9-dihydro-purin-6-one