Technology Process of (3RS,5R,2'R,3'S,6'S,8'S,10'R)-O-3-(10'-diphenyl-t-butylsiloxy-2',3'-dimethyl-1'7'-dioxaspiro<5.5>undecan-8'-yl)-3,5-dimethyl-6-thiophenylhex-1-enyl S-methyl thiocarbonate
There total 13 articles about (3RS,5R,2'R,3'S,6'S,8'S,10'R)-O-3-(10'-diphenyl-t-butylsiloxy-2',3'-dimethyl-1'7'-dioxaspiro<5.5>undecan-8'-yl)-3,5-dimethyl-6-thiophenylhex-1-enyl S-methyl thiocarbonate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 10 steps
1: sodium iodide / acetone / Ambient temperature
2: 1.) butyl-lithium, di-isopropylamine / 1.) hexane, THF, -78 deg C --> room temp., 10 min; 2.) THF, -78 deg C; -20 deg C, 5 d
3: 58 percent / LiAlH4 / tetrahydrofuran / 2 h / 0 °C / 2.) room temp., overnight
4: pyridine / room temp., overnight
5: lithium bromide / tetrahydrofuran / room temp., overnight
6: 64 percent / tetrahydrofuran; liquid ammonia
7: 1.) zirconocene dichloride; 2.) iodine / 1.) hexane, dichloromethane, room temp., overnight; 2.) THF
8: t-butyl-lithium / tetrahydrofuran / 1 h / -80 °C
9: tetrahydrofuran / 2 h / -80 °C
With
lithium aluminium tetrahydride; n-butyllithium; zirconocene dichloride; iodine; tert.-butyl lithium; diisopropylamine; sodium iodide; lithium bromide;
In
tetrahydrofuran; pyridine; ammonia; acetone;
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 1.) butyl-lithium, di-isopropylamine / 1.) hexane, THF, -78 deg C --> room temp., 10 min; 2.) THF, -78 deg C; -20 deg C, 5 d
2: 58 percent / LiAlH4 / tetrahydrofuran / 2 h / 0 °C / 2.) room temp., overnight
3: pyridine / room temp., overnight
4: lithium bromide / tetrahydrofuran / room temp., overnight
5: 64 percent / tetrahydrofuran; liquid ammonia
6: 1.) zirconocene dichloride; 2.) iodine / 1.) hexane, dichloromethane, room temp., overnight; 2.) THF
7: t-butyl-lithium / tetrahydrofuran / 1 h / -80 °C
8: tetrahydrofuran / 2 h / -80 °C
With
lithium aluminium tetrahydride; n-butyllithium; zirconocene dichloride; iodine; tert.-butyl lithium; diisopropylamine; lithium bromide;
In
tetrahydrofuran; pyridine; ammonia;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: pyridine / room temp., overnight
2: lithium bromide / tetrahydrofuran / room temp., overnight
3: 64 percent / tetrahydrofuran; liquid ammonia
4: 1.) zirconocene dichloride; 2.) iodine / 1.) hexane, dichloromethane, room temp., overnight; 2.) THF
5: t-butyl-lithium / tetrahydrofuran / 1 h / -80 °C
6: tetrahydrofuran / 2 h / -80 °C
With
zirconocene dichloride; iodine; tert.-butyl lithium; lithium bromide;
In
tetrahydrofuran; pyridine; ammonia;
