<(2',3',4',6'-tetra-O-acetyl-1'-thio-β-D-galactopyranosyl)oxy>-3,6-dioxaoctyl 11-(5-cholesten-3β-yloxy)-3,6,9-trioxaundecanyl 2,5-dichlorophenyl phosphorothioate

Base Information

Chemical Name:<(2',3',4',6'-tetra-O-acetyl-1'-thio-β-D-galactopyranosyl)oxy>-3,6-dioxaoctyl 11-(5-cholesten-3β-yloxy)-3,6,9-trioxaundecanyl 2,5-dichlorophenyl phosphorothioate
CAS No.:132156-13-9
Molecular Formula:C₆₁H₉₅Cl₂O₁₈PS₂
Molecular Weight:1282.43
Hs Code.:

<(2',3',4',6'-tetra-O-acetyl-1'-thio-β-D-galactopyranosyl)oxy>-3,6-dioxaoctyl 11-(5-cholesten-3β-yloxy)-3,6,9-trioxaundecanyl 2,5-dichlorophenyl phosphorothioate

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Chemical Property of <(2',3',4',6'-tetra-O-acetyl-1'-thio-β-D-galactopyranosyl)oxy>-3,6-dioxaoctyl 11-(5-cholesten-3β-yloxy)-3,6,9-trioxaundecanyl 2,5-dichlorophenyl phosphorothioate

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Technology Process of <(2',3',4',6'-tetra-O-acetyl-1'-thio-β-D-galactopyranosyl)oxy>-3,6-dioxaoctyl 11-(5-cholesten-3β-yloxy)-3,6,9-trioxaundecanyl 2,5-dichlorophenyl phosphorothioate

There total 8 articles about <(2',3',4',6'-tetra-O-acetyl-1'-thio-β-D-galactopyranosyl)oxy>-3,6-dioxaoctyl 11-(5-cholesten-3β-yloxy)-3,6,9-trioxaundecanyl 2,5-dichlorophenyl phosphorothioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 132156-10-6
11-(cholest-5-en-3β-yloxy)-3,6,9-trioxaundecan-1-ol

: Acetic acid (2S,3R,4S,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[2-(2-{2-[(2,5-dichloro-phenoxy)-(6-trifluoromethyl-benzotriazol-1-yloxy)-thiophosphoryloxy]-ethoxy}-ethoxy)-ethylsulfanyl]-tetrahydro-pyran-3-yl ester

: 132156-13-9,132203-33-9
<(2',3',4',6'-tetra-O-acetyl-1'-thio-β-D-galactopyranosyl)oxy>-3,6-dioxaoctyl 11-(5-cholesten-3β-yloxy)-3,6,9-trioxaundecanyl 2,5-dichlorophenyl phosphorothioate

Guidance literature:: In 1,4-dioxane; at 20 ℃; for 1h;
DOI:10.1021/jm00107a024

Reference yield:

: 5197-62-6
2-[2-(chloroethoxy)ethoxy]ethanol

: 132156-13-9,132203-33-9
<(2',3',4',6'-tetra-O-acetyl-1'-thio-β-D-galactopyranosyl)oxy>-3,6-dioxaoctyl 11-(5-cholesten-3β-yloxy)-3,6,9-trioxaundecanyl 2,5-dichlorophenyl phosphorothioate

Guidance literature:: Multi-step reaction with 4 steps

1: NaI / butan-2-one / 16 h / Heating

2: 90 percent / N,N-diisopropylethylamine (DIPEA) / butan-2-one / 1 h / Ambient temperature

3: dioxane / 0.25 h

4: 79 percent / dioxane / 1 h / 20 °C

With N-ethyl-N,N-diisopropylamine; sodium iodide; In 1,4-dioxane; butanone;
DOI:10.1021/jm00107a024

Reference yield:

: 87668-61-9
2,5-dichlorophenyl phosphorodichloridothioate

: 132156-13-9,132203-33-9
<(2',3',4',6'-tetra-O-acetyl-1'-thio-β-D-galactopyranosyl)oxy>-3,6-dioxaoctyl 11-(5-cholesten-3β-yloxy)-3,6,9-trioxaundecanyl 2,5-dichlorophenyl phosphorothioate

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / dioxane / 1 h / Ambient temperature

2: dioxane / 0.25 h

3: 79 percent / dioxane / 1 h / 20 °C

With pyridine; In 1,4-dioxane;
DOI:10.1021/jm00107a024