Technology Process of (R)-4-(3-ethoxy-4-methoxyphenyl)pyrrolidin-2-one
There total 8 articles about (R)-4-(3-ethoxy-4-methoxyphenyl)pyrrolidin-2-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
N,N-dimethyl-formamide;
for 42h;
Inert atmosphere;
DOI:10.1021/jm200070e
- Guidance literature:
-
Multi-step reaction with 7 steps
1: Triphenylphosphine oxide; N,N,N',N'-tetramethylguanidine / 24 h / 75 °C / Inert atmosphere
2: sodium hydroxide / methanol; water / 16 h / 0 - 20 °C / Inert atmosphere
3: thionyl chloride / dichloromethane / 16 h / Inert atmosphere; Reflux
4: dichloromethane / 2 h / Reflux; Inert atmosphere
5: palladium 10% on activated carbon; hydrogen / ethanol; ethyl acetate / 90 °C / 67506.8 Torr
6: para-xylene / 36 h / 160 °C / Inert atmosphere; Autoclave
7: potassium carbonate / N,N-dimethyl-formamide / 42 h / Inert atmosphere
With
thionyl chloride; palladium 10% on activated carbon; hydrogen; potassium carbonate; Triphenylphosphine oxide; sodium hydroxide; N,N,N',N'-tetramethylguanidine;
In
methanol; ethanol; dichloromethane; para-xylene; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm200070e
- Guidance literature:
-
Multi-step reaction with 5 steps
1: thionyl chloride / dichloromethane / 16 h / Inert atmosphere; Reflux
2: dichloromethane / 2 h / Reflux; Inert atmosphere
3: palladium 10% on activated carbon; hydrogen / ethanol; ethyl acetate / 90 °C / 67506.8 Torr
4: para-xylene / 36 h / 160 °C / Inert atmosphere; Autoclave
5: potassium carbonate / N,N-dimethyl-formamide / 42 h / Inert atmosphere
With
thionyl chloride; palladium 10% on activated carbon; hydrogen; potassium carbonate;
In
ethanol; dichloromethane; para-xylene; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm200070e
