2-phenyl-2,3-dihydro-4(1H)-quinazolinone

Base Information

• Chemical Name: 2-phenyl-2,3-dihydro-4(1H)-quinazolinone
• CAS No.: 121998-76-3
• Molecular Formula: C₁₄H₁₂N₂O
• Molecular Weight: 224.262
• Mol file: 121998-76-3.mol

Synonyms:

Chemical Property of 2-phenyl-2,3-dihydro-4(1H)-quinazolinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-phenyl-2,3-dihydro-4(1H)-quinazolinone

There total 48 articles about 2-phenyl-2,3-dihydro-4(1H)-quinazolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

benzaldehyde (100-52-7) + anthranilic acid amide (28144-70-9,88-68-6) → 2-phenyl-2,3-dihydro-4(1H)-quinazolinone (121998-76-3,954-91-6)

Guidance literature:

In water; at 120 ℃; for 16h; sealed tube;

DOI:10.1021/jo301282n

Reference yield: 98.0%

isatoic anhydride (118-48-9) + benzaldehyde (100-52-7) → 2-phenyl-2,3-dihydro-4(1H)-quinazolinone (121998-76-3,954-91-6)

Guidance literature:

With ammonium acetate; In water; at 80 ℃; for 1h; Green chemistry;

DOI:10.1002/aoc.6116

Reference yield: 96.0%

benzaldehyde (100-52-7) + anthranilic acid nitrile (1885-29-6) → 2-phenyl-2,3-dihydro-4(1H)-quinazolinone (121998-76-3,954-91-6)

Guidance literature:

With cholin hydroxide; In water; at 80 ℃; for 0.5h; Reagent/catalyst; Temperature; Solvent; Green chemistry;

DOI:10.1039/c6ra15574j

upstream raw materials:

benzaldehyde

anthranilic acid nitrile

2-phenyl-tetrahydro-(2H)-1,3-oxazine

anthranilic acid amide

Downstream raw materials:

2-phenyl-4(3H)-quinazolinone

benzaldehyde

anthranilic acid amide

(S)-2-cyclohexyl-2,3-dihydroquinazolin-4(1H)-one

Refernces

• 1、 Ghorbani-Choghamarani, Arash,Azadi, Gouhar. "Synthesis, characterization, and application of Fe3O4-SA-PPCA as a novel nanomagnetic reusable catalyst for the efficient synthesis of 2,3-dihydroquinazolin-4(1H)-ones and polyhydroquinolines". . p. 9752 - 9758. Retrieved 2015.
• 2、 Salehi, Peyman,Dabiri, Minoo,Baghbanzadeh, Mostafa,Bahramnejad, Mahboobeh. "One-pot, three-component synthesis of 2,3-dihydro-4(1H)-quinazolinones by montmorillonite K-10 as an efficient and reusable catalyst". . p. 2287 - 2292. Retrieved 2006.
• 3、 Tamaddon, Fatemeh,KazemiVarnamkhasti, MohammadTaghi. "Scalable preparation, characterization, and application of alkali-treated starch as a new organic base catalyst". . p. 9 - 15. Retrieved 2017.
• 4、 Mohammadi, Mohammad Kazem,Saghanezhad, Seyyed Jafar,Razzaghiasl, Nima. "DABCO containing acidic poly(ionic liquid): An efficient catalyst for the one-pot preparation of 2,3-dihydroquinazoline-4(1H)-ones". . p. 535 - 544. Retrieved 2017.
• 5、 Saffar-Teluri, Ali,Bolouk, Shiva. "One-pot, three-component synthesis of 2,3-dihydroquinazolin-4(1H)-ones using p-Toluenesulfonic acid-paraformaldehyde copolymer as an efficient and reusable catalyst". . p. 1113 - 1115. Retrieved 2010.
• 6、 Rostamizadeh, Shahnaz,Amani, Ali Mohammad,Aryan, Reza,Ghaieni, Hamid Reza,Shadjou, Nasrin. "Synthesis of new 2-aryl substituted 2,3-dihydroquinazoline-4(1H)-ones under solvent-free conditions, using molecular iodine as a mild and efficient catalyst". . p. 3567 - 3576. Retrieved 2008.
• 7、 Shiri, Lotfi,Heidari, Leili,Kazemi, Mosstafa. "Magnetic Fe3O4 nanoparticles supported imine/Thiophene-nickel (II) complex: A new and highly active heterogeneous catalyst for the synthesis of polyhydroquinolines and 2, 3-dihydroquinazoline-4(1H)-ones". . . Retrieved 2018.
• 8、 Khaksar, Samad,Talesh, Saeed Mohammadzadeh. "Three-component one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives in 2,2,2-trifluoroethanol". . p. 779 - 783. Retrieved 2012.
• 9、 Salehi, Peyman,Dabiri, Minoo,Zolfigol, Mohammad Ali,Baghbanzadeh, Mostafa. "A novel method for the one-pot three-component synthesis of 2,3-dihydroquinazolin-4(1H)-ones". . p. 1155 - 1157. Retrieved 2005.
• 10、 Su, Weike,Yang, Bibo. "Reductive cyclization of nitro and azide compounds with aldehydes and ketones promoted by metallic samarium and catalytic amount of iodine". . p. 695 - 697. Retrieved 2002.