Methoxydiphenylphosphine

Base Information

• Chemical Name: Methoxydiphenylphosphine
• CAS No.: 4020-99-9
• Molecular Formula: C13H13OP
• Molecular Weight: 216.219
• Hs Code.: 29310099
• European Community (EC) Number: 223-683-9
• NSC Number: 171167
• DSSTox Substance ID: DTXSID80193202
• Nikkaji Number: J217.833H
• Wikidata: Q72473295
• Mol file: 4020-99-9.mol

Synonyms:Methoxydiphenylphosphine;4020-99-9;Methyl diphenylphosphinite;methoxy(diphenyl)phosphane;Diphenylphosphinous Acid Methyl Ester;Phosphinous acid, diphenyl-, methyl ester;EINECS 223-683-9;MFCD00048025;methyldiphenyl phosphinite;P(OC)(c1ccccc1)c2ccccc2;SCHEMBL187947;Methyl diphenylphosphinite, 97%;DTXSID80193202;AMY19756;C13-H13-O-P;NSC171167;AKOS015905171;NSC 171167;NSC-171167;CS-0085666;D2557;FT-0625275;F10242;A824980

Chemical Property of Methoxydiphenylphosphine

Chemical Property:

• Appearance/Colour: Colorless to light yellow liqui
• Vapor Pressure: 0.00207mmHg at 25°C
• Refractive Index: n20/D 1.604(lit.)
• Boiling Point: 299.852 °C at 760 mmHg
• Flash Point: 163.693 °C
• PSA: 22.82000
• Density: 1.078g/mLat 25°C(lit.)
• LogP: 2.68070
• Storage Temp.: 0-6°C
• Sensitive.: Air & Moisture Sensitive
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 216.070402032
• Heavy Atom Count: 15
• Complexity: 153

Purity/Quality:

98% ^*data from raw suppliers

Methyl diphenylphosphinite ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,Xn
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 26-37/39-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Other Classes -> Phosphite Compounds
• Canonical SMILES: COP(C1=CC=CC=C1)C2=CC=CC=C2
• Uses: Ased as:Catalyst for hydroformylative desymmetrization of bisalkenyl carbinols and bishomoallylic carbinolsLigand in rhodium-catalyzed hydroformylation of bishomoallylic alcoholsCalatyst in preparation of γ-lactones via branched-regioselective hydroformylation reactionsLigand for nickel-catalyzed hydrocyanation reactionsCatalyst in annulation reactions

Technology Process of Methoxydiphenylphosphine

There total 23 articles about Methoxydiphenylphosphine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.9%

diphenyl-phosphinic acid (1707-03-5) + methyl iodide (74-88-4) → diphenylphosphinous acid methyl ester (4020-99-9)

Guidance literature:

With dodecatungstosilic acid; In N,N-dimethyl-formamide; at 100 ℃; for 4h; Reagent/catalyst; Solvent; Temperature; Inert atmosphere;

Reference yield: 95.6%

5-methoxy-4,4-dimethyl-5,5-diphenyl-Δ2-1,2,5λ5-oxazaphospholine 2-oxide (81200-74-0) → 1-Nitro-2-methyl-1-propen (1606-30-0) + diphenylphosphinous acid methyl ester (4020-99-9)

Guidance literature:

at 85 ℃; for 0.5h; under 0.1 Torr;

Reference yield: 85.0%

methanol (67-56-1) + chloro-diphenylphosphine (1079-66-9,74391-44-9) → diphenylphosphinous acid methyl ester (4020-99-9)

Guidance literature:

With triethylamine; In diethyl ether; at 0 - 20 ℃;

DOI:10.1002/anie.200802296

upstream raw materials:

methanol

chloro-diphenylphosphine

trifluoroacetic acid-methyl ester

(dimethylamino)(diphenyl)phosphine

Downstream raw materials:

diphenyltrichloromethylphosphine oxide

(α-diphenylphosphinoyl-benzyliden)-amidophosphoric acid diphenyl ester

diphenyl(acetyl)phosphine oxide

2-Methoxy-4,4,5,5-tetramethyl-2,2-diphenyl-2λ⁵-[1,3,2]dioxaphospholane

Refernces

• 1、 Chamkin, Aleksandr A.,Krivykh, Vasily V.,Kreindlin, Arkady Z.,Dolgushin, Fedor M.,Ustynyuk, Nikolai A.. "Reactions of Ferrocenium Hexafluorophosphate with P?OR Nucleophiles Give Ring C?H Functionalization or Ring Replacement Products Depending on the Phosphorus Reagent". . p. 1601 - 1610. Retrieved 2021/04/16.
• 2、 -. "Preparation method of material compound". Paragraph 0044-0049; 0062-0063. . Retrieved 2021/04/10.