(S)-2-[[(2S,3S,5R)-3-Azido-5-(5-methyl-2,4-dioxo-tetrahydro-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxy]-(4-bromo-phenoxy)-phosphorylamino]-propionic acid methyl ester

Base Information

• Chemical Name: (S)-2-[[(2S,3S,5R)-3-Azido-5-(5-methyl-2,4-dioxo-tetrahydro-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxy]-(4-bromo-phenoxy)-phosphorylamino]-propionic acid methyl ester
• CAS No.: 213906-39-9
• Molecular Formula: C₂₀H₂₆BrN₆O₈P
• Molecular Weight: 589.34

Synonyms:

Chemical Property of (S)-2-[[(2S,3S,5R)-3-Azido-5-(5-methyl-2,4-dioxo-tetrahydro-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxy]-(4-bromo-phenoxy)-phosphorylamino]-propionic acid methyl ester

Chemical Property:

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Technology Process of (S)-2-[[(2S,3S,5R)-3-Azido-5-(5-methyl-2,4-dioxo-tetrahydro-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxy]-(4-bromo-phenoxy)-phosphorylamino]-propionic acid methyl ester

There total 2 articles about (S)-2-[[(2S,3S,5R)-3-Azido-5-(5-methyl-2,4-dioxo-tetrahydro-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxy]-(4-bromo-phenoxy)-phosphorylamino]-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-bromo-phenol (106-41-2) → (S)-2-[[(2S,3S,5R)-3-Azido-5-(5-methyl-2,4-dioxo-tetrahydro-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxy]-(4-bromo-phenoxy)-phosphorylamino]-propionic acid methyl ester (213906-39-9)

Guidance literature:

Multi-step reaction with 3 steps

1: POCl₃

2: CH₂Cl₂ / -78 °C

3: tetrahydrofuran

With trichlorophosphate; In tetrahydrofuran; dichloromethane;

DOI:10.1002/jat.762

Reference yield:

p-bromophenyl phosphorodichloridate (19430-76-3) → (S)-2-[[(2S,3S,5R)-3-Azido-5-(5-methyl-2,4-dioxo-tetrahydro-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxy]-(4-bromo-phenoxy)-phosphorylamino]-propionic acid methyl ester (213906-39-9)

Guidance literature:

Multi-step reaction with 2 steps

1: CH₂Cl₂ / -78 °C

2: tetrahydrofuran

In tetrahydrofuran; dichloromethane;

DOI:10.1002/jat.762

Reference yield:

methanol (67-56-1) + (S)-2-[[(2S,3S,5R)-3-Azido-5-(5-methyl-2,4-dioxo-tetrahydro-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxy]-(4-bromo-phenoxy)-phosphorylamino]-propionic acid methyl ester (213906-39-9) → 5-bromo-6-methoxy-5,6-dihydro-3'-azidothymidine-5'-(p-bromophenyl) methoxyalaninyl phosphate (213982-96-8)

Guidance literature:

With bromine;

DOI:10.1002/jat.762

upstream raw materials:

4-bromo-phenol

p-bromophenyl phosphorodichloridate

Downstream raw materials:

5-bromo-6-methoxy-5,6-dihydro-3'-azidothymidine-5'-(p-bromophenyl) methoxyalaninyl phosphate

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