AgoMelatine (hydrochloride)

Base Information

• Chemical Name: AgoMelatine (hydrochloride)
• CAS No.: 1176316-99-6
• Molecular Formula: C₁₅H₁₇NO₂*ClH
• Molecular Weight: 279.766
• Mol file: 1176316-99-6.mol

Synonyms:

Chemical Property of AgoMelatine (hydrochloride)

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Agomelatinehydrochloride >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of AgoMelatine (hydrochloride)

There total 6 articles about AgoMelatine (hydrochloride) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-(7-methoxynaphthalen-1-yl)ethanamine hydrochloride (139525-77-2) + acetic anhydride (108-24-7) → Agomelatine hydrochloride (1176316-99-6)

Guidance literature:

2-(7-methoxynaphthalen-1-yl)ethanamine hydrochloride; acetic anhydride; With sodium acetate; In ethanol; Reflux;

With hydrogenchloride; In ethyl acetate; at 20 ℃; for 1h; Product distribution / selectivity;

Reference yield: 92.0%

sodium acetate (127-09-3) + 2-(7-methoxynaphthalen-1-yl)ethanamine hydrochloride (139525-77-2) + acetic anhydride (108-24-7) → Agomelatine hydrochloride (1176316-99-6)

Guidance literature:

In ethanol; Product distribution / selectivity; Reflux;

Reference yield: 88.7%

agomelatine (138112-76-2) → Agomelatine hydrochloride (1176316-99-6)

Guidance literature:

With hydrogenchloride; In water; ethyl acetate; at 10 ℃; Product distribution / selectivity;

upstream raw materials:

agomelatine

2-(7-methoxynaphthalen-1-yl)ethanamine hydrochloride

acetic anhydride

sodium acetate