MMP-3 INHIBITOR VIII

Base Information

Chemical Name:MMP-3 INHIBITOR VIII
CAS No.:208663-26-7
Molecular Formula:C₂₀H₂₆N₂O₅S
Molecular Weight:406.503
Hs Code.:
Mol file:208663-26-7.mol

Synonyms:

Suppliers and Price of MMP-3 INHIBITOR VIII

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Cayman Chemical
MMP-3 Inhibitor VIII ≥95%
1mg
$ 102.00

Cayman Chemical
MMP-3 Inhibitor VIII ≥95%
500μg
$ 64.00

Cayman Chemical
MMP-3 Inhibitor VIII ≥95%
5mg
$ 319.00

American Custom Chemicals Corporation
MMP-3 INHIBITOR VIII 95.00%
5MG
$ 498.75

AK Scientific
MMP-3InhibitorVIII
1mg
$ 226.00

Total 3 raw suppliers

Chemical Property of MMP-3 INHIBITOR VIII

Chemical Property:

Purity/Quality:

98%Min ^*data from raw suppliers

MMP-3 Inhibitor VIII ≥95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description Matrix metalloproteinases (MMPs) belong to a family of proteases that play a crucial role in tissue remodeling and repair by degrading extracellular matrix proteins to enable cell migration. MMP-3 (also known as stromelysin-1) is thought to play a role in the vascular remodeling that occurs during aneurysm formation and may also be involved in wound repair, progression of atherosclerosis, and tumor initiation. MMP-3 inhibitor VIII is a cell permeable sulfonamide-based hydroxamic acid that binds to the active site of MMP-3 (Ki = 23 nM) and prevents its activity. MMP-3 INHIBITOR VIII has also been shown to inhibit mouse macrophage metalloelastase MME/MMP-12 with an IC50 value of 13 nM.

Technology Process of MMP-3 INHIBITOR VIII

There total 9 articles about MMP-3 INHIBITOR VIII which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79-37-8
oxalyl dichloride

: 2(R)-[[4-methoxybenzenesulfonyl](benzyl)amino]-4-methylpentanoic acid

: 208663-26-7
N-Hydroxy-2(R)-[[4-methoxybenzenesulfonyl]-(benzyl)amino]-4-methylpentanamide

Guidance literature:: With hydroxylamine hydrochloride; triethylamine; In tetrahydrofuran; N-methyl-acetamide; dichloromethane; water;

Reference yield:

: 1026556-88-6
(R)-2-[Benzyl-(4-methoxy-benzenesulfonyl)-amino]-4-methyl-pentanoic acid tert-butoxy-amide

: 208663-26-7
N-hydroxy-2(R)-{[(4-methoxyphenyl)sulfonyl]-[benzyl]amino}-4-methylpentanamide

Guidance literature:: With hydrogenchloride; In ethanol; dichloromethane; for 48h; Ambient temperature;
DOI:10.1021/jm960871c

Reference yield:

: 328-38-1,21675-61-6,25248-98-0,70-45-1
(R)-leucine

: 208663-26-7
N-hydroxy-2(R)-{[(4-methoxyphenyl)sulfonyl]-[benzyl]amino}-4-methylpentanamide

Guidance literature:: Multi-step reaction with 6 steps

1: Et₃N / dioxane; H₂O / Ambient temperature

2: toluene / 3 h / 95 °C

3: K₂CO₃ / dimethylformamide / 48 h / Ambient temperature

4: HCl gas / CH₂Cl₂ / 4 h / Ambient temperature

5: 1-hydroxybenzotriazole, 4-methylmorpholine, N-<(dimethylamino)propyl>-N'-ethylcarbodiimide*HCl / CH₂Cl₂

6: HCl gas / CH₂Cl₂; ethanol / 48 h / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm960871c